Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 440847..441532 Replicon chromosome
Accession NZ_CP063362
Organism Xanthobacter sp. YN2

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag EZH22_RS02120 Protein ID WP_203196334.1
Coordinates 440847..441272 (-) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag EZH22_RS02125 Protein ID WP_203196335.1
Coordinates 441272..441532 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EZH22_RS02105 436445..437656 + 1212 WP_203194167.1 outer membrane protein transport protein -
EZH22_RS02110 438074..439233 + 1160 Protein_420 acetyl-CoA C-acetyltransferase -
EZH22_RS02115 439381..440610 + 1230 WP_203194168.1 FAD-dependent oxidoreductase -
EZH22_RS02120 440847..441272 - 426 WP_203196334.1 type II toxin-antitoxin system VapC family toxin Toxin
EZH22_RS02125 441272..441532 - 261 WP_203196335.1 plasmid stabilization protein Antitoxin
EZH22_RS02130 441525..441805 - 281 Protein_424 chromosome partitioning protein ParB -
EZH22_RS02135 442036..442809 - 774 WP_203194169.1 enoyl-CoA hydratase -
EZH22_RS02140 442836..443383 - 548 Protein_426 hypothetical protein -
EZH22_RS02145 443495..444493 - 999 WP_203194170.1 TRAP transporter substrate-binding protein DctP -
EZH22_RS02150 444567..445631 - 1065 WP_203194171.1 branched-chain amino acid ABC transporter permease -
EZH22_RS02155 445635..446525 - 891 WP_203194172.1 branched-chain amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 306128..543886 237758


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15144.63 Da        Isoelectric Point: 8.5604

>T178014 WP_203196334.1 NZ_CP063362:c441272-440847 [Xanthobacter sp. YN2]
MILVDTNVISEPMTKVPDARVIAWIDAQAIETLYLSAVTLAELRFGIAVLPAGKRRDRLRARLEDEVLPLFADRVLPFDL
AASEAYARLMAQARKRGTAIGKADGFIAAIAASRSLVVATRDAAPFETAGLAVLNPWQAAG

Download         Length: 426 bp

>T178014 NZ_CP083815:c74643-74293 [Enterobacter asburiae]
ATGTGGACGGTTCTGTTCGGTAAGGTATTCGAGCAATGGCTGCTTGAACAGGAAGAAGGATTACAGGATAAGGTACTGGC
AGACCTGCTAAATCTGCAAAAATATGGGCCACGTCTTCCACGGCCCTATGCTGATACGGTTAAAGGCTCATGGTATAACC
ATATGAAAGAATTACGTATTCAATATGCTGGACGTCCGATACGTGCTTTCTTCGCATTTGATCCTGTCCGTCAGGCCATT
GTGCTTTGCGCGGGCGATAAGAGTAACGACAAAGCCTTTTATGAAAAAATGATTCGCATCGCAGATACCGAATTTTCCTT
CCATCTGACAAGCCTGGAGGCAACCAAGTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9557.87 Da        Isoelectric Point: 10.7098

>AT178014 WP_203196335.1 NZ_CP063362:c441532-441272 [Xanthobacter sp. YN2]
MPAITIRNRSAETHRALKVRAARHGRSTEAEVRDILEQAAKPEGRIRLVSLPAEIGREARLSDKERAIFESAIARDKAPA
DPISFD

Download         Length: 261 bp

>AT178014 NZ_CP083815:c74296-73997 [Enterobacter asburiae]
GTGAAAACCTTAAATGAAGTGATTGCGTCACGTTCACCGGAAAGCCAACAACGTATTAAAGAGATGGCAGATGAAATGAT
CCTCGAGACGGGTCTGCAACTTTTACGTGAAGAGCTGAGACTTTCGCAAAAAAATGTTGCCGATTTGATGGGGGTGAGTC
AGCCCGCAGTAACGCAGCTAGAGCAACGTGGAAATGAACTCAAAATTGCCACGCTTAAGCGCTACATTGAGGCAATGGGG
GGGAAACTTCATATCGATATTGAACTTCCCACAGGAAAACGCGTTGCATTTCATATCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References