Detailed information of TA system TA178014

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 440847..441532
• Replicon: chromosome
• Accession: NZ_CP063362
• Organism: Xanthobacter sp. YN2

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: EZH22_RS02120
• Protein ID: WP_203196334.1
• Coordinates: 440847..441272 (-)
• Length: 142 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: EZH22_RS02125
• Protein ID: WP_203196335.1
• Coordinates: 441272..441532 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EZH22_RS02105	436445..437656	+	1212	WP_203194167.1	outer membrane protein transport protein	-
EZH22_RS02110	438074..439233	+	1160	Protein_420	acetyl-CoA C-acetyltransferase	-
EZH22_RS02115	439381..440610	+	1230	WP_203194168.1	FAD-dependent oxidoreductase	-
EZH22_RS02120	440847..441272	-	426	WP_203196334.1	type II toxin-antitoxin system VapC family toxin	Toxin
EZH22_RS02125	441272..441532	-	261	WP_203196335.1	plasmid stabilization protein	Antitoxin
EZH22_RS02130	441525..441805	-	281	Protein_424	chromosome partitioning protein ParB	-
EZH22_RS02135	442036..442809	-	774	WP_203194169.1	enoyl-CoA hydratase	-
EZH22_RS02140	442836..443383	-	548	Protein_426	hypothetical protein	-
EZH22_RS02145	443495..444493	-	999	WP_203194170.1	TRAP transporter substrate-binding protein DctP	-
EZH22_RS02150	444567..445631	-	1065	WP_203194171.1	branched-chain amino acid ABC transporter permease	-
EZH22_RS02155	445635..446525	-	891	WP_203194172.1	branched-chain amino acid ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	306128..543886	237758

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-124)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 142 a.a.
• Molecular weight: 15144.63 Da
• Isoelectric Point: 8.5604

>T178014 WP_203196334.1 NZ_CP063362:c441272-440847 [Xanthobacter sp. YN2]
MILVDTNVISEPMTKVPDARVIAWIDAQAIETLYLSAVTLAELRFGIAVLPAGKRRDRLRARLEDEVLPLFADRVLPFDL
AASEAYARLMAQARKRGTAIGKADGFIAAIAASRSLVVATRDAAPFETAGLAVLNPWQAAG

Nucleotide

• Length: 426 bp

>T178014 NZ_CP083815:c74643-74293 [Enterobacter asburiae]
ATGTGGACGGTTCTGTTCGGTAAGGTATTCGAGCAATGGCTGCTTGAACAGGAAGAAGGATTACAGGATAAGGTACTGGC
AGACCTGCTAAATCTGCAAAAATATGGGCCACGTCTTCCACGGCCCTATGCTGATACGGTTAAAGGCTCATGGTATAACC
ATATGAAAGAATTACGTATTCAATATGCTGGACGTCCGATACGTGCTTTCTTCGCATTTGATCCTGTCCGTCAGGCCATT
GTGCTTTGCGCGGGCGATAAGAGTAACGACAAAGCCTTTTATGAAAAAATGATTCGCATCGCAGATACCGAATTTTCCTT
CCATCTGACAAGCCTGGAGGCAACCAAGTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9557.87 Da
• Isoelectric Point: 10.7098

>AT178014 WP_203196335.1 NZ_CP063362:c441532-441272 [Xanthobacter sp. YN2]
MPAITIRNRSAETHRALKVRAARHGRSTEAEVRDILEQAAKPEGRIRLVSLPAEIGREARLSDKERAIFESAIARDKAPA
DPISFD

Nucleotide

• Length: 261 bp

>AT178014 NZ_CP083815:c74296-73997 [Enterobacter asburiae]
GTGAAAACCTTAAATGAAGTGATTGCGTCACGTTCACCGGAAAGCCAACAACGTATTAAAGAGATGGCAGATGAAATGAT
CCTCGAGACGGGTCTGCAACTTTTACGTGAAGAGCTGAGACTTTCGCAAAAAAATGTTGCCGATTTGATGGGGGTGAGTC
AGCCCGCAGTAACGCAGCTAGAGCAACGTGGAAATGAACTCAAAATTGCCACGCTTAAGCGCTACATTGAGGCAATGGGG
GGGAAACTTCATATCGATATTGAACTTCCCACAGGAAAACGCGTTGCATTTCATATCTAA