Detailed information of TA system TA178013

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ParE-CopA/RHH(antitoxin)
• Location: 5777391..5778015
• Replicon: chromosome
• Accession: NZ_CP063361
• Organism: Massilia violaceinigra strain sipir

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: INH39_RS26715
• Protein ID: WP_243490166.1
• Coordinates: 5777713..5778015 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: copA
• Uniprot ID: -
• Locus tag: INH39_RS26710
• Protein ID: WP_243490165.1
• Coordinates: 5777391..5777675 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
INH39_RS26685 (INH39_26570)	5772785..5773237	-	453	WP_243490161.1	DUF4124 domain-containing protein	-
INH39_RS26690 (INH39_26575)	5773250..5774686	-	1437	WP_243490162.1	FAD-binding oxidoreductase	-
INH39_RS26695 (INH39_26580)	5774683..5775087	-	405	WP_167080358.1	DUF2069 domain-containing protein	-
INH39_RS26700 (INH39_26585)	5775088..5775699	-	612	WP_243490163.1	NAD(P)H:quinone oxidoreductase	-
INH39_RS26705 (INH39_26590)	5775819..5777174	+	1356	WP_243490164.1	YihY family inner membrane protein	-
INH39_RS26710 (INH39_26595)	5777391..5777675	+	285	WP_243490165.1	CopG family ribbon-helix-helix protein	Antitoxin
INH39_RS26715 (INH39_26600)	5777713..5778015	+	303	WP_243490166.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
INH39_RS26720 (INH39_26605)	5778035..5778340	-	306	WP_243490167.1	DUF962 domain-containing protein	-
INH39_RS26725 (INH39_26610)	5778363..5779178	-	816	WP_243490168.1	alpha/beta hydrolase	-
INH39_RS26730 (INH39_26615)	5779180..5780490	-	1311	WP_243490169.1	O-acetylhomoserine aminocarboxypropyltransferase	-
INH39_RS26735 (INH39_26620)	5780712..5781164	+	453	WP_166874557.1	CBS domain-containing protein	-
INH39_RS26740 (INH39_26625)	5781166..5782056	+	891	WP_279401117.1	PhzF family phenazine biosynthesis protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-98)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11314.26 Da
• Isoelectric Point: 12.0353

>T178013 WP_243490166.1 NZ_CP063361:5777713-5778015 [Massilia violaceinigra]
MRAPVPHLRFSTRALLDLKRLREFLQPKSPAAAKRAAQAIVKSLRVLSQRPRLGRPIPNLPFGNYEFVISYGNAGYIARY
RFTDGVVTILSVRHQKEASP

Nucleotide

• Length: 303 bp

>T178013 NZ_CP083810:78902-79318 [Pantoea agglomerans]
GTGATTAAAACCTATATGCTCGATACAAATATCTGCTCTTTTATTATGCGGGAACAGCCGGAAGCCGTACTCATGCGGCT
GGAGCAAGCTGTGCTGCGTCGTCATCGAATTGTTGTGTCGGCGATAACCTATGCGGAAATGCGGTTTGGCGCTGTTGGCA
AGAAAGCGTCGCCTCGCCATGTACAGCTGGTTGAAGCGTTCTGCGCGCGCCTGGATGCCATTCTGGCCTGGGATCGCCAT
GCAGTGGACGCAACCACAGAAATCAAGCGTGCGCTGACCGCTATTGACAGGCCCATTGGCCCGAATGATACCGCCATTGC
CGGGCACGCTATTGCGGCTGACGCCATGCTTGTTACCCATAACGTCAAGGAATTTGAGCGCGTGCCAGGGCTTGTTTTTG
AAGACTGGAGCAAATGA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 11047.25 Da
• Isoelectric Point: 4.2622

>AT178013 WP_243490165.1 NZ_CP063361:5777391-5777675 [Massilia violaceinigra]
MSDFTSLALELDRETQRRLNRLAEARQLSPHLMMNEAIAQYLEREEKSEVFRQETLDSWNEYQATGLHVTGEEVIAWLET
WGEENELPAPECHK

Nucleotide

• Length: 285 bp

>AT178013 NZ_CP083810:78675-78905 [Pantoea agglomerans]
ATGCGTACGGTATCGATATTCAAAAACGGTAATAATCGGGCGATTCGCCTGCCGCGCGATCTCGATTTCGACGGCGTAAA
CGAACTGGAGATTATTCGCGAAGGCGACTCTCTGATCCTGCGACCAGTCAAGCCGAGCTGGGGGTCATTTCGCGAGCAAG
AAAAGGCTGACGCCGATTTTATGACGGAGCGTGCAGACGTTTTCAGCGATGAAGGGCGATTTGAGCTGTGA