Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 544011..544647 Replicon chromosome
Accession NZ_CP063360
Organism Bacillus altitudinis strain BIM B-263

Toxin (Protein)


Gene name mazF Uniprot ID K2MHT4
Locus tag INQ56_RS02605 Protein ID WP_003214169.1
Coordinates 544297..544647 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A267X601
Locus tag INQ56_RS02600 Protein ID WP_012008995.1
Coordinates 544011..544292 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INQ56_RS02580 540157..540762 - 606 WP_007496491.1 rhomboid family intramembrane serine protease -
INQ56_RS02585 540857..541222 + 366 WP_061418041.1 holo-ACP synthase -
INQ56_RS02590 541383..542399 + 1017 WP_007496489.1 outer membrane lipoprotein-sorting protein -
INQ56_RS02595 542535..543716 + 1182 WP_061418044.1 alanine racemase -
INQ56_RS02600 544011..544292 + 282 WP_012008995.1 hypothetical protein Antitoxin
INQ56_RS02605 544297..544647 + 351 WP_003214169.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
INQ56_RS02610 544762..545592 + 831 WP_017358395.1 STAS domain-containing protein -
INQ56_RS02615 545597..545965 + 369 WP_003214235.1 RsbT antagonist protein RsbS -
INQ56_RS02620 545968..546369 + 402 WP_003214085.1 anti-sigma regulatory factor -
INQ56_RS02625 546380..547387 + 1008 WP_061418047.1 PP2C family protein-serine/threonine phosphatase -
INQ56_RS02630 547447..547776 + 330 WP_007496474.1 anti-sigma factor antagonist -
INQ56_RS02635 547773..548261 + 489 WP_007496471.1 anti-sigma B factor RsbW -
INQ56_RS02640 548227..549015 + 789 WP_193804104.1 RNA polymerase sigma factor SigB -
INQ56_RS02645 549015..549614 + 600 WP_024719202.1 SpoIIE family protein phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12976.99 Da        Isoelectric Point: 5.1663

>T178011 WP_003214169.1 NZ_CP063360:544297-544647 [Bacillus altitudinis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEINAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVDEALQVSLALIDF

Download         Length: 351 bp

>T178011 NZ_CP083809:3527783-3528115 [Pantoea agglomerans]
ATGGAGCGCGGCGAAATCTGGCTGGTTTCACTCGATCCTACAGCCGGTCATGAGCAACAAGGCACGCGTCCCGTATTGAT
AGTCTCGCCTGCGGCTTTTAATCAGCTAACGCAAACACCCGTTGTATTACCCATAACAACTGGCGGAAGTTTTGCCCGTA
CCGCAGGCTTCGCAGTATCACTCGATGAGGCTGGTACACGTACCCGAGGCGTTATTCGCTGTGATCAGCCACGTGCGATT
GATATGCGAGCTCGTCAAGGTAAGCGGCTGGAGAAAATTCCAGCCGACGTGATGGCAGAGGTACAGGCAATTTTGCGTGC
GATACTCATTTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10894.27 Da        Isoelectric Point: 5.2726

>AT178011 WP_012008995.1 NZ_CP063360:544011-544292 [Bacillus altitudinis]
MSESSATNEMKIRLPETLMSEIERVAEQDKVTRNELIYRATKTYIRERNIRQNRESMRRGYMEMAKINLNISSEAQYAEF
EAENTVERLVSGG

Download         Length: 282 bp

>AT178011 NZ_CP083809:3527526-3527783 [Pantoea agglomerans]
ATGCATACGACCCATCTTCGTAAAGTAGGCGGCTCTGTTATGTTAGCCGTCCCCCCCGCTCTGCTCGATATCCTTCAGCT
CAGTGCCGATGCGCAGGTTGGTCTTACCGTCGATAACGGCCGTCTGATTATCGAACCTAAACCTGTTCCCAGCTACACGT
TGTCTGAGTTGCTGGCTAAATGCGACCCCAATGCGGAACTGACGGATGAAGATCGTCAGTGGCTTAATGCCACGCCAGTA
GGTAAAGAGGAACTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K2MHT4

Antitoxin

Source ID Structure
AlphaFold DB A0A267X601

References