Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 1887020..1887655 Replicon chromosome
Accession NZ_CP063356
Organism Anaerobacillus isosaccharinicus strain NB2006

Toxin (Protein)


Gene name mazF Uniprot ID A0A1S2MFS5
Locus tag AWH56_RS09455 Protein ID WP_071315458.1
Coordinates 1887305..1887655 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag AWH56_RS09450 Protein ID WP_083388403.1
Coordinates 1887020..1887298 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AWH56_RS09430 1882354..1882710 + 357 WP_071315404.1 holo-ACP synthase -
AWH56_RS09435 1882886..1884430 + 1545 WP_071315403.1 bifunctional ADP-dependent NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase -
AWH56_RS09440 1884493..1885518 + 1026 WP_071315402.1 outer membrane lipoprotein-sorting protein -
AWH56_RS09445 1885698..1886867 + 1170 WP_071315401.1 alanine racemase -
AWH56_RS09450 1887020..1887298 + 279 WP_083388403.1 ribbon-helix-helix protein, CopG family Antitoxin
AWH56_RS09455 1887305..1887655 + 351 WP_071315458.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
AWH56_RS09460 1887996..1888814 + 819 WP_071315399.1 STAS domain-containing protein -
AWH56_RS09465 1888837..1889193 + 357 WP_071315398.1 STAS domain-containing protein -
AWH56_RS09470 1889196..1889594 + 399 WP_071315397.1 anti-sigma regulatory factor -
AWH56_RS09475 1889609..1890622 + 1014 WP_071315396.1 PP2C family protein-serine/threonine phosphatase -
AWH56_RS09480 1890673..1891005 + 333 WP_071315395.1 STAS domain-containing protein -
AWH56_RS09485 1891002..1891490 + 489 WP_083388402.1 anti-sigma B factor RsbW -
AWH56_RS09490 1891450..1892235 + 786 WP_071315394.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(7-44)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12929.92 Da        Isoelectric Point: 6.4673

>T178008 WP_071315458.1 NZ_CP063356:1887305-1887655 [Anaerobacillus isosaccharinicus]
IVVKRGDVYFADLSPVVGSEQGGVRPVLIIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEINAKRYGFDRDSVILLEQV
RTIDKQRLTDKITHLDDDMMSRVNEALQISLGLIDF

Download         Length: 351 bp

>T178008 NZ_CP083809:1696883-1696969 [Pantoea agglomerans]
GCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCAAAGAGCCATTTCCCTGGACCGAATACAGGAATCGTGTTCGGTC
TTTTTTT

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10573.06 Da        Isoelectric Point: 7.2044

>AT178008 WP_083388403.1 NZ_CP063356:1887020-1887298 [Anaerobacillus isosaccharinicus]
VSANTKRITVSLPQHLLNEVDGLIKRENVNRSEFISQATKEYLREKKKRQIRETMQQGYMEMAKINLNIAAEAFLAEEEA
EHTRTLDLVSGV

Download         Length: 279 bp

>AT178008 NZ_CP083809:c1696969-1696883 [Pantoea agglomerans]
AAAAAAAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTTGAGAGCCGTGCGCTAAAAGTTGGCATTAA
TGCAGGC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1S2MFS5

Antitoxin

Source ID Structure

References