Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 1887020..1887655 Replicon chromosome
Accession NZ_CP063356
Organism Anaerobacillus isosaccharinicus strain NB2006

Toxin (Protein)


Gene name mazF Uniprot ID A0A1S2MFS5
Locus tag AWH56_RS09455 Protein ID WP_071315458.1
Coordinates 1887305..1887655 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag AWH56_RS09450 Protein ID WP_083388403.1
Coordinates 1887020..1887298 (+) Length 93 a.a.

Genomic Context

AWH56_RS09430AWH56_RS09435AWH56_RS09440AWH56_RS09445AWH56_RS09450AWH56_RS09455AWH56_RS09460AWH56_RS09465AWH56_RS09470AWH56_RS09475AWH56_RS09480AWH56_RS09485AWH56_RS09490
Location: 1882354..1882710 (357 bp)
Type: Others
Protein ID: WP_071315404.1
Location: 1882886..1884430 (1545 bp)
Type: Others
Protein ID: WP_071315403.1
Location: 1884493..1885518 (1026 bp)
Type: Others
Protein ID: WP_071315402.1
Location: 1885698..1886867 (1170 bp)
Type: Others
Protein ID: WP_071315401.1
Location: 1887020..1887298 (279 bp)
Type: Antitoxin
Protein ID: WP_083388403.1
Location: 1887305..1887655 (351 bp)
Type: Toxin
Protein ID: WP_071315458.1
Location: 1887996..1888814 (819 bp)
Type: Others
Protein ID: WP_071315399.1
Location: 1888837..1889193 (357 bp)
Type: Others
Protein ID: WP_071315398.1
Location: 1889196..1889594 (399 bp)
Type: Others
Protein ID: WP_071315397.1
Location: 1889609..1890622 (1014 bp)
Type: Others
Protein ID: WP_071315396.1
Location: 1890673..1891005 (333 bp)
Type: Others
Protein ID: WP_071315395.1
Location: 1891002..1891490 (489 bp)
Type: Others
Protein ID: WP_083388402.1
Location: 1891450..1892235 (786 bp)
Type: Others
Protein ID: WP_071315394.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
AWH56_RS094301882354..1882710+357WP_071315404.1holo-ACP synthase-
AWH56_RS094351882886..1884430+1545WP_071315403.1bifunctional ADP-dependent NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase-
AWH56_RS094401884493..1885518+1026WP_071315402.1outer membrane lipoprotein-sorting protein-
AWH56_RS094451885698..1886867+1170WP_071315401.1alanine racemase-
AWH56_RS094501887020..1887298+279WP_083388403.1ribbon-helix-helix protein, CopG familyAntitoxin
AWH56_RS094551887305..1887655+351WP_071315458.1type II toxin-antitoxin system PemK/MazF family toxinToxin
AWH56_RS094601887996..1888814+819WP_071315399.1STAS domain-containing protein-
AWH56_RS094651888837..1889193+357WP_071315398.1STAS domain-containing protein-
AWH56_RS094701889196..1889594+399WP_071315397.1anti-sigma regulatory factor-
AWH56_RS094751889609..1890622+1014WP_071315396.1PP2C family protein-serine/threonine phosphatase-
AWH56_RS094801890673..1891005+333WP_071315395.1STAS domain-containing protein-
AWH56_RS094851891002..1891490+489WP_083388402.1anti-sigma B factor RsbW-
AWH56_RS094901891450..1892235+786WP_071315394.1RNA polymerase sigma factor SigB-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(7-44)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12929.92 Da        Isoelectric Point: 6.4673

>T178008 WP_071315458.1 NZ_CP063356:1887305-1887655 [Anaerobacillus isosaccharinicus]
IVVKRGDVYFADLSPVVGSEQGGVRPVLIIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEINAKRYGFDRDSVILLEQV
RTIDKQRLTDKITHLDDDMMSRVNEALQISLGLIDF

Download         Length: 351 bp

>T178008 NZ_CP083809:1696883-1696969 [Pantoea agglomerans]
GCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCAAAGAGCCATTTCCCTGGACCGAATACAGGAATCGTGTTCGGTC
TTTTTTT

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10573.06 Da        Isoelectric Point: 7.2044

>AT178008 WP_083388403.1 NZ_CP063356:1887020-1887298 [Anaerobacillus isosaccharinicus]
VSANTKRITVSLPQHLLNEVDGLIKRENVNRSEFISQATKEYLREKKKRQIRETMQQGYMEMAKINLNIAAEAFLAEEEA
EHTRTLDLVSGV

Download         Length: 279 bp

>AT178008 NZ_CP083809:c1696969-1696883 [Pantoea agglomerans]
AAAAAAAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTTGAGAGCCGTGCGCTAAAAGTTGGCATTAA
TGCAGGC

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A1S2MFS5

Antitoxin

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Source
ID
Structure
No matching records found

References