Detailed information of TA system TA177998

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 3018024..3018549
• Replicon: chromosome
• Accession: NZ_CP063354
• Organism: Serratia marcescens strain SCQ1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: CA266_RS14270
• Protein ID: WP_015377296.1
• Coordinates: 3018024..3018308 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A8B4GIN1
• Locus tag: CA266_RS14275
• Protein ID: WP_004928423.1
• Coordinates: 3018298..3018549 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CA266_RS14245	3013284..3014417	+	1134	WP_033640832.1	putrescine ABC transporter ATP-binding subunit PotG	-
CA266_RS14250	3014442..3015404	+	963	WP_016928361.1	putrescine ABC transporter permease PotH	-
CA266_RS14255	3015401..3016246	+	846	WP_193842685.1	putrescine ABC transporter permease PotI	-
CA266_RS14260	3016351..3016830	+	480	WP_028127974.1	YbjO family protein	-
CA266_RS14265	3016900..3018027	+	1128	WP_151254362.1	23S rRNA (uracil(747)-C(5))-methyltransferase RlmC	-
CA266_RS14270	3018024..3018308	-	285	WP_015377296.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CA266_RS14275	3018298..3018549	-	252	WP_004928423.1	prevent-host-death protein	Antitoxin
CA266_RS14280	3018651..3019385	-	735	WP_016928355.1	arginine ABC transporter substrate-binding protein	-
CA266_RS14285	3019586..3020254	-	669	WP_033637817.1	arginine ABC transporter permease ArtM	-
CA266_RS14290	3020254..3020970	-	717	WP_028127976.1	arginine ABC transporter permease ArtQ	-
CA266_RS14295	3020980..3021711	-	732	WP_004928409.1	arginine ABC transporter substrate-binding protein	-
CA266_RS14300	3021744..3022472	-	729	WP_016928352.1	arginine ABC transporter ATP-binding protein ArtP	-
CA266_RS14305	3022736..3023278	-	543	WP_028127978.1	lipoprotein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-83)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10803.94 Da
• Isoelectric Point: 10.6941

>T177998 WP_015377296.1 NZ_CP063354:c3018308-3018024 [Serratia marcescens]
MTYKLEFEEHALKEFKKLSPVIREQFKKKLASVLVNPHIPANKLAGLPDCYKIKLRASGFRLVYRVMETEIVVLVLSVGK
RERSAAYTAAKKRL

Nucleotide

• Length: 285 bp

>T177998 NZ_CP083805:c1899367-1899212 [Staphylococcus argenteus]
ATGTCTAAAGATAAAGATGCAAAATTAAATTATCACGAAGAAGAAAACAGTATGGTAACTGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAGATGGAACAAATTTCAGATCAAAATGATCAAGAGAAGAGTACTGATGAAAAGAATAGCCATTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9108.39 Da
• Isoelectric Point: 4.5203

>AT177998 WP_004928423.1 NZ_CP063354:c3018549-3018298 [Serratia marcescens]
MTVQPILADSAVSISDFKKSPNAALKEAQGQPVAVLTNGKISGYYVSPETWEAIAEYLEDIELAEIVRSRMNGKRIKVNL
DDL

Nucleotide

• Length: 252 bp

>AT177998 NZ_CP083805:c1899999-1899400 [Staphylococcus argenteus]
ATGGCAATGAACTTTAAAGTATTTGACAACAGTCAACTTGTAGCAGAATATGCTGCAGATATTATTAGAAAACAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTGGATACAGACCAAGCACCAGTATTAGATGAACTAAAGAAAAATGTTG
AGAAACACGCTGTTGATTTTAGTCAAATAAATATTTTAGATTATGACAATAAAAAATCTTATTTTGAAGCATTAGGCGTG
CCAGCAAGTCAAATCTATCCAATTGCGTTTGAAAAAGATGCTATTGAATTTATCTCTGACAAAATTAAAACTAAAGAAAA
TAAAGGCAAACTAACATTACAAGTTGTTTCTATTGATGAGCATGGAAAATTAAATGTTAGTATCCGCCAAGGTTTAATGG
AAGCGAGAGAAATATTTTTAGTTGTGACAGGTGCTAATAAAAAGGAAGTTGTTGAAAAATTATACCAAGAAAATGGTAAA
ACAAGTTTCGAACCATCTGACTTAAAATCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTCAAAGCTTACTTTACATCTCGCTTTGCTTAA

Structures

Antitoxin

• AlphaFold DB: A0A8B4GIN1