Detailed information of TA system TA177997

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 2889722..2890269
• Replicon: chromosome
• Accession: NZ_CP063354
• Organism: Serratia marcescens strain SCQ1

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: A0A086G3V8
• Locus tag: CA266_RS13695
• Protein ID: WP_033633716.1
• Coordinates: 2889961..2890269 (+)
• Length: 103 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: -
• Locus tag: CA266_RS13690
• Protein ID: WP_025302143.1
• Coordinates: 2889722..2889958 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CA266_RS13675	2886208..2887743	+	1536	WP_016928459.1	glutathione ABC transporter substrate-binding protein GsiB	-
CA266_RS13680	2887796..2888716	+	921	WP_016928458.1	glutathione ABC transporter permease GsiC	-
CA266_RS13685	2888726..2889634	+	909	WP_016928457.1	glutathione ABC transporter permease GsiD	-
CA266_RS13690	2889722..2889958	+	237	WP_025302143.1	type II toxin-antitoxin system CcdA family antitoxin	Antitoxin
CA266_RS13695	2889961..2890269	+	309	WP_033633716.1	CcdB family protein	Toxin
CA266_RS13700	2890306..2891148	-	843	WP_015377214.1	S-formylglutathione hydrolase	-
CA266_RS13705	2891163..2892287	-	1125	WP_016928454.1	S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase	-
CA266_RS13710	2892318..2893238	-	921	WP_016928453.1	LysR family transcriptional regulator	-
CA266_RS13715	2893344..2894501	+	1158	WP_033640883.1	YbfB/YjiJ family MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin CcdB (2-101)

Antitoxin

• Post-segregation antitoxin CcdA (8-78)

Sequences

Toxin

Protein

• Length: 103 a.a.
• Molecular weight: 11448.21 Da
• Isoelectric Point: 5.0196

>T177997 WP_033633716.1 NZ_CP063354:2889961-2890269 [Serratia marcescens]
MQFTVYDNTYPASAYPYLLDVQSDLIDALSTRLMIPLYALDNVRVKISARLCPEIEVNGEKFLVMTHEMAAVRISQLGKA
VGNANEHRNQIKAAIDFLIDGF

Nucleotide

• Length: 309 bp

>T177997 NZ_CP083805:c876954-876766 [Staphylococcus argenteus]
ATGACTTTACATTTTGCAATTTTATTTTGGCTAGCATTAATTTTTATCGTTGCTGGTACATTTATATTTGTCTTAATGAA
AAAAACTGCTAAAGAATCTAAAAAAGAATCTTATTTAAGCTTCGCTGTTATTTTCTATATTTTTGGATTCGCAATGCTAA
TTTATACATTAATATTTGGAATTCTTTAA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8967.04 Da
• Isoelectric Point: 5.0807

>AT177997 WP_025302143.1 NZ_CP063354:2889722-2889958 [Serratia marcescens]
MANSNVTKKTVNVTIDRDLFQRAKSLGVNVSSVLTDALSVRVRDIEIQQWREQNRAALEELNRITEENGLLSDEYRTF

Nucleotide

• Length: 237 bp

>AT177997 NZ_CP083805:c877243-876983 [Staphylococcus argenteus]
ATGAAAAACATTCAATTAAATGCTATAAATTTAGTTATAACAATCATATTTGCTATCTTTAACATTATGATTACATATAA
CAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGCATTATCATTTGCGGTTCGATACTCATTGTATCGTTTACCATTG
CAATGATTACTAAATTCTGGTTAAGTGAAATATTATTTTTTATTAACATCGTGCTCGTTCTTTATTATATTTATCCAATT
TTTTATGATTTCATTAATTAA

Structures

Toxin

• AlphaFold DB: A0A086G3V8