Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2401707..2402328 Replicon chromosome
Accession NZ_CP063354
Organism Serratia marcescens strain SCQ1

Toxin (Protein)


Gene name Hha Uniprot ID A0A8B4G7F9
Locus tag CA266_RS11260 Protein ID WP_004940313.1
Coordinates 2401707..2401910 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A2X2G5J9
Locus tag CA266_RS11265 Protein ID WP_004940312.1
Coordinates 2401960..2402328 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CA266_RS11230 2397409..2397747 + 339 WP_049299676.1 P-II family nitrogen regulator -
CA266_RS11235 2397783..2399069 + 1287 WP_049299675.1 ammonium transporter AmtB -
CA266_RS11240 2399160..2400023 - 864 WP_016928847.1 acyl-CoA thioesterase II -
CA266_RS11245 2400254..2400745 + 492 WP_016928846.1 YbaY family lipoprotein -
CA266_RS11250 2400810..2401124 - 315 WP_004940317.1 MGMT family protein -
CA266_RS11260 2401707..2401910 - 204 WP_004940313.1 hemolysin expression modulator Hha Toxin
CA266_RS11265 2401960..2402328 - 369 WP_004940312.1 Hha toxicity modulator TomB Antitoxin
CA266_RS11270 2402487..2402840 - 354 WP_016928845.1 hypothetical protein -
CA266_RS11275 2403245..2403958 + 714 WP_049299731.1 ABC transporter ATP-binding protein -
CA266_RS11280 2403955..2404812 + 858 WP_164052909.1 metal ABC transporter permease -
CA266_RS11285 2404838..2405716 + 879 WP_097102650.1 metal ABC transporter substrate-binding protein -
CA266_RS11290 2405824..2405964 - 141 WP_004940304.1 type B 50S ribosomal protein L36 -
CA266_RS11295 2405977..2406231 - 255 WP_004940303.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8107.37 Da        Isoelectric Point: 6.9756

>T177996 WP_004940313.1 NZ_CP063354:c2401910-2401707 [Serratia marcescens]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPTSVWKYVR

Download         Length: 204 bp

>T177996 NZ_CP083804:c3944424-3944230 [Xanthomonas translucens pv. pistacia]
ATGCCCCCGAAAATCCGCGACGTGCTGCAACAACTCAAGGACGCAGGCTGGCAGCAAGTCGGCCAGACCGGCAGCCACCG
CCAGTTCAAGCATCCTGTCTACCCAGGCCGCGTGACAGTGGCCGGCAAGCCGAGCGATGATGTGGCTCCCGGCACCCTGA
ACAGCATCCTGAAGCAAGCCGGCTTGAAGAGGTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14261.95 Da        Isoelectric Point: 4.4314

>AT177996 WP_004940312.1 NZ_CP063354:c2402328-2401960 [Serratia marcescens]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSSVNLQLNELIEHIASFVMSYKIKYMDESDLSELVEEYL
DDTYTLFSSYGINDSDLRRWQKTKARLFRMFSGEDICTTMKT

Download         Length: 369 bp

>AT177996 NZ_CP083804:c3944224-3944012 [Xanthomonas translucens pv. pistacia]
ATGCGCTACGCCGTCGTCATCGAGCAAGCGGGGAACAACTACTCTGCCTACGTGCCGGATCTGCCGGGGTGTGTGGCGAC
GGGTGCGACCACCGCGGAGGTTGAGGGATTGATCCGCGAAGCGATCGAGTTGCATCTGGCCGGTATGCGCGAGGACGGGG
AGGTGATTCCGGTGCCGTCGAGTCAGGTGGAGTATGTGGATGTGGCGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B4G7F9

Antitoxin

Source ID Structure
AlphaFold DB A0A2X2G5J9

References