Detailed information of TA system TA177993

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 568462..568934
• Replicon: chromosome
• Accession: NZ_CP063354
• Organism: Serratia marcescens strain SCQ1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A5C7D428
• Locus tag: CA266_RS02690
• Protein ID: WP_049208401.1
• Coordinates: 568462..568737 (-)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A8G2LC23
• Locus tag: CA266_RS02695
• Protein ID: WP_016930068.1
• Coordinates: 568743..568934 (-)
• Length: 64 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CA266_RS02665	563781..565061	-	1281	WP_123867893.1	polysaccharide deacetylase family protein	-
CA266_RS02670	565239..566009	-	771	WP_193843088.1	ABC transporter permease	-
CA266_RS02675	566006..566929	-	924	WP_015379030.1	ABC transporter ATP-binding protein	-
CA266_RS02680	567140..567796	+	657	WP_016930066.1	carbonate dehydratase	-
CA266_RS02685	567835..568371	-	537	WP_004937527.1	hypoxanthine phosphoribosyltransferase	-
CA266_RS02690	568462..568737	-	276	WP_049208401.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CA266_RS02695	568743..568934	-	192	WP_016930068.1	hypothetical protein	Antitoxin
CA266_RS02700	569040..570683	-	1644	WP_049300404.1	multicopper oxidase CueO	-
CA266_RS02705	570900..571247	+	348	WP_033634347.1	YacC family pilotin-like protein	-
CA266_RS02710	571373..572236	+	864	WP_016930071.1	polyamine aminopropyltransferase	-
CA266_RS02715	572264..573058	+	795	WP_004937510.1	adenosylmethionine decarboxylase	-
CA266_RS02720	573091..573453	-	363	WP_016930072.1	protein YacL	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10410.13 Da
• Isoelectric Point: 6.8785

>T177993 WP_049208401.1 NZ_CP063354:c568737-568462 [Serratia marcescens]
MLTVKWTDEAKTGLYTLLAFIAERNPLAAEALLQRIEESVIPLAEHPYLFRPGRVNGTREMVVHPNYIVVYRVLAAHIEI
VSVLHARQEYP

Nucleotide

• Length: 276 bp

>T177993 NZ_CP083804:3280770-3281021 [Xanthomonas translucens pv. pistacia]
ATGGACACCATCACCTATAGCGCTGCACGCGCCGCCCTTGCGGACACCATGGAGCGCGTCGTCAACAACCACGAGCCGGT
GATCATCACCCGCAGCCGCGAGCAATCCGTGGTCATGCTGTCGCTTGAAGACTACAAGGCGATGGAGGAAACCGCCTACC
TGCTGCGCAGTCCGAAGAGCGCGCAGCGCCTGCTGGAATCCATCGCCCAGCTCGAGGCCGGTCGCGGCAAGGCACGGGAC
CTGGCCGAGTGA

Antitoxin

Protein

• Length: 64 a.a.
• Molecular weight: 7178.94 Da
• Isoelectric Point: 5.6492

>AT177993 WP_016930068.1 NZ_CP063354:c568934-568743 [Serratia marcescens]
MPTKLDPIVSEFETQEQADSYDRWFRSTVESSINSDSSRIPHDEVMAGARHIIEQAKAKRKSA

Nucleotide

• Length: 192 bp

>AT177993 NZ_CP083804:3281018-3281275 [Xanthomonas translucens pv. pistacia]
GTGACGCTTCAGTTCTCGGACAATGCCTGGGAGGACGACCTCTACTGGCAGCAAACCGACAAGAAGATGCTCAAGCGCGT
CAACGATCTGATCAAAGCCATTCAACGCGATCCCTTCCAAGGCGTCGGCAAGCCAGAACCGCTACGCCATGCCTTGGCCG
GCTATTGGTCGCGGCGCATCAACGACGAACATCGCATCGTGTACAAGGTCGAGGCGGGCGTCCTGCTGATCGCGCAGGTG
CGGTATCACTACGCGTAG

Structures

Toxin

• AlphaFold DB: A0A5C7D428