Detailed information of TA system TA177972

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PanAT/DUF4065(antitoxin)
• Location: 1569686..1570674
• Replicon: chromosome
• Accession: NZ_CP063349
• Organism: Escherichia coli strain BS15R-A

Toxin (Protein)

• Gene name: panT
• Uniprot ID: -
• Locus tag: IN859_RS07485
• Protein ID: WP_014640052.1
• Coordinates: 1570288..1570674 (+)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: panA
• Uniprot ID: A0A0J5Z6D5
• Locus tag: IN859_RS07480
• Protein ID: WP_000458584.1
• Coordinates: 1569686..1570258 (+)
• Length: 191 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IN859_RS07450	1564767..1565375	+	609	WP_000646078.1	transcriptional repressor LexA	-
IN859_RS07455	1565448..1566773	+	1326	WP_001298861.1	MATE family efflux transporter DinF	-
IN859_RS07460	1566889..1567098	+	210	WP_001030593.1	CsbD family protein	-
IN859_RS07465	1567140..1567655	-	516	WP_001295691.1	zinc uptake transcriptional repressor Zur	-
IN859_RS07470	1567973..1568964	+	992	Protein_1435	DUF2713 family protein	-
IN859_RS07475	1569328..1569450	+	123	WP_001300034.1	hypothetical protein	-
IN859_RS07480	1569686..1570258	+	573	WP_000458584.1	SocA family protein	Antitoxin
IN859_RS07485	1570288..1570674	+	387	WP_014640052.1	hypothetical protein	Toxin
IN859_RS07490	1570714..1570887	+	174	WP_000390072.1	hypothetical protein	-
IN859_RS07495	1570935..1571216	-	282	WP_001093917.1	pyocin activator PrtN family protein	-
IN859_RS07500	1571253..1571825	-	573	WP_001061348.1	3'-5' exoribonuclease	-
IN859_RS07505	1571825..1572634	-	810	WP_000206745.1	hypothetical protein	-
IN859_RS07510	1572634..1572996	-	363	WP_130569182.1	hypothetical protein	-
IN859_RS07515	1572987..1573523	-	537	WP_000008210.1	5'-deoxynucleotidase	-
IN859_RS07520	1573651..1574475	-	825	WP_151288104.1	DUF2303 family protein	-
IN859_RS07525	1574541..1574903	-	363	WP_000135680.1	hypothetical protein	-
IN859_RS07530	1574918..1575228	-	311	Protein_1447	hypothetical protein	-
IN859_RS07535	1575342..1575533	+	192	WP_000159356.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1564767..1610464	45697

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin SocA-like, Panacea domain (27-137)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14465.40 Da
• Isoelectric Point: 5.4833

>T177972 WP_014640052.1 NZ_CP063349:1570288-1570674 [Escherichia coli]
VLAPTGPCNHLHVICNDPVYYPVNDCYCVLVVNISSIKDGVPHDPSCVLNSGDHRFIKHPSYVVYAEAIIWRVDNMVRKQ
RSGEISVHDDMPEATFNRILDGFDISDEVTPKNLKFKNKYCVSSIDDE

Nucleotide

• Length: 387 bp

>T177972 NZ_CP083790:c4889922-4889638 [Klebsiella variicola]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGATGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Protein

• Length: 191 a.a.
• Molecular weight: 21973.21 Da
• Isoelectric Point: 6.0283

>AT177972 WP_000458584.1 NZ_CP063349:1569686-1570258 [Escherichia coli]
MFCEEKVAQMAAYLLLKRGGRMAYLKLMKLLYLSNRQSILKHGRMIGEDSLYSMKFGPVMSNTLNLIRGKAEGIGDYWYN
LIETNGHNVSLRSDPREMDADEVFDELSRADIRILDEIYSRYGHMNRFDLANMTHLESVCPEWHDPGNSRKPIDLKEMLI
SEGKSEDEANRIIGKMEESQKLKEFSLQLS

Nucleotide

• Length: 573 bp

>AT177972 NZ_CP083790:c4890154-4889912 [Klebsiella variicola]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Structures

Antitoxin

• AlphaFold DB: A0A0J5Z6D5