Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 3737..4259 Replicon plasmid pBS90R-A_3
Accession NZ_CP063344
Organism Escherichia coli strain BS90R-A

Toxin (Protein)


Gene name relE Uniprot ID G3CAN5
Locus tag IN877_RS24260 Protein ID WP_000220560.1
Coordinates 3978..4259 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G3CAG1
Locus tag IN877_RS24255 Protein ID WP_000121743.1
Coordinates 3737..3988 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IN877_RS24240 688..1113 - 426 WP_000202942.1 hypothetical protein -
IN877_RS24245 1181..1627 - 447 Protein_2 hypothetical protein -
IN877_RS24250 1667..2503 - 837 WP_001050931.1 replication initiation protein -
IN877_RS24255 3737..3988 + 252 WP_000121743.1 plasmid stabilization protein Antitoxin
IN877_RS24260 3978..4259 + 282 WP_000220560.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IN877_RS24265 4334..5031 + 698 Protein_6 IS1 family transposase -
IN877_RS24270 5072..5386 + 315 WP_000734776.1 IncN plasmid KikA protein -
IN877_RS24275 5422..5733 + 312 WP_001452736.1 hypothetical protein -
IN877_RS24280 5942..6424 + 483 WP_077874353.1 restriction endonuclease -
IN877_RS24285 6418..7115 - 698 Protein_10 IS1 family transposase -
IN877_RS24290 7149..7742 - 594 WP_000599943.1 DUF1449 family protein -
IN877_RS24295 8011..8211 + 201 WP_046788569.1 cell surface composition regulator GlgS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid tet(A) - 1..27893 27893


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11005.83 Da        Isoelectric Point: 10.5938

>T177967 WP_000220560.1 NZ_CP063344:3978-4259 [Escherichia coli]
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADLR

Download         Length: 282 bp

>T177967 NZ_CP083790:1833896-1834228 [Klebsiella variicola]
ATGGACAGAGGGGAAATCTGGCTTGTTTCACTGGATCCGATTGCTGGCCACGAGCAAAGTGGAAAACGTCCGGTCCTCAT
TGTATCGAAGGCATCGTTTAACAAGCTGACCCGGCTACCGGTCGTGGTTCCCGTCACCAGCGGCGGAAACTTTGCACGTA
CAGCAGGCTTCACGGTTTCACTGGAAGAGGCGGGGACCAAAACAACAGGCGTTATTCGCTGCGACCAGCCCAGAACTATC
GATATGGCGGCCCGGAACGGCAAGCGTCTGGAACGCATACCTGACGCCGTTGTCAATGAAGTGCTTGCCAGGCTGGATGC
GATTCTCAGTTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9194.43 Da        Isoelectric Point: 4.1683

>AT177967 WP_000121743.1 NZ_CP063344:3737-3988 [Escherichia coli]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL

Download         Length: 252 bp

>AT177967 NZ_CP083790:1833638-1833895 [Klebsiella variicola]
ATGTACAAAACTCGCCTGAAAAAGGTTGGCGGATCCATCATGCTGGCGGTTCCTCCCGCCGTGCTGAAAGCGCTGGAGCT
GTCGACAGACAGCGAAGTGGGTATGACTATAGATAATGGCTGCCTGATTATTGAACCGCAGAAACGGCCCCATTATTCGC
TTGAGGAACTGTTGGCGCAGTGCGATCCGCACGCCGAAATGAGCGAAGAGGATCGGGAATGGATTGATGCGCCTGCGGTG
GGCAAGGAGATTCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G3CAN5

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5I301

References