Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 3610096..3610785 Replicon chromosome
Accession NZ_CP063341
Organism Escherichia coli strain BS90R-A

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag IN877_RS17265 Protein ID WP_001460496.1
Coordinates 3610096..3610434 (-) Length 113 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag IN877_RS17270 Protein ID WP_001460495.1
Coordinates 3610459..3610785 (-) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IN877_RS17245 3605186..3607384 + 2199 WP_000667026.1 aldehyde oxidoreductase molybdenum-binding subunit PaoC -
IN877_RS17250 3607394..3608350 + 957 WP_000121356.1 molybdenum cofactor insertion chaperone PaoD -
IN877_RS17255 3608401..3608739 + 339 Protein_3374 LysR family transcriptional regulator -
IN877_RS17260 3609098..3609949 - 852 WP_097447682.1 hypothetical protein -
IN877_RS17265 3610096..3610434 - 339 WP_001460496.1 TA system toxin CbtA family protein Toxin
IN877_RS17270 3610459..3610785 - 327 WP_001460495.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
IN877_RS17275 3610828..3611307 - 480 WP_097447683.1 DNA repair protein RadC -
IN877_RS17280 3611320..3611766 - 447 WP_050561233.1 antirestriction protein -
IN877_RS17285 3611845..3612663 - 819 WP_097447684.1 DUF945 domain-containing protein -
IN877_RS17290 3613126..3613749 + 624 WP_001461983.1 inovirus Gp2 family protein -
IN877_RS17295 3613868..3614083 + 216 WP_001461982.1 AlpA family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-107)

Antitoxin

Antitoxin CbeA

(7-107)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 12771.67 Da        Isoelectric Point: 8.5253

>T177952 WP_001460496.1 NZ_CP063341:c3610434-3610096 [Escherichia coli]
MKTLPANQRVAKPCPPPVLVWQTLLTRLLEQHYGLTLNDTPFSDETVIQEHINAGITLADAVNFLVEKYELVRIDRRGFN
CQEQSPYLRAVDILRARQATGLLRQSHHPSAR

Download         Length: 339 bp

>T177952 NZ_CP083784:819297-819707 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12552.27 Da        Isoelectric Point: 6.3682

>AT177952 WP_001460495.1 NZ_CP063341:c3610785-3610459 [Escherichia coli]
MEKHDTPEWGLRCDVMPRFSARLVQKNNRLHYLADRAGITGAFKEEECHQLNSAFPHFIEQMELMLLSGELNPRHAHRVT
LYHDELTCEADTLGSCGYVYMAIYPTQR

Download         Length: 327 bp

>AT177952 NZ_CP083784:819050-819316 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References