Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 559182..560770 Replicon chromosome
Accession NZ_CP063332
Organism Escherichia coli strain BS74R-D

Toxin (Protein)


Gene name hipA Uniprot ID S1ELM3
Locus tag IN878_RS02785 Protein ID WP_001125439.1
Coordinates 559182..560504 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag IN878_RS02790 Protein ID WP_001301023.1
Coordinates 560504..560770 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IN878_RS02770 554541..556001 - 1461 Protein_546 hypothetical protein -
IN878_RS02775 555998..557548 - 1551 WP_000086929.1 site-specific integrase -
IN878_RS02780 557532..558407 - 876 WP_001059072.1 site-specific integrase -
IN878_RS02785 559182..560504 - 1323 WP_001125439.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
IN878_RS02790 560504..560770 - 267 WP_001301023.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
IN878_RS02795 560993..562393 - 1401 WP_001422930.1 autotransporter outer membrane beta-barrel domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 524630..560770 36140


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-401)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49275.82 Da        Isoelectric Point: 8.2482

>T177902 WP_001125439.1 NZ_CP063332:c560504-559182 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTHPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVESNVLRLHGRLSREYGSK

Download         Length: 1323 bp

>T177902 NZ_CP083754:c1857786-1857433 [Serratia marcescens]
GTGTGGGAAATTAAAACAACGGATGCATTTGATCATTGGTACAGATCGCTCAGCGATGCCGATCGGGCCGGCGTACTTGC
CGCATTGATGGTCCTGCGGGAAAAGGGGCCGGGGCTGCCCAGACCCTATGCCGATACGGTTAAAGGCTCACGTTACAGCA
ATATGAAAGAGTTGCGCATTCAGTGCCGAGGCGAACCGTTGCGGGCATTCTTCGCTTTCGATCCGTACCGTATTGGCATT
GTGCTTTGCGCGGGCAATAAAGCCGGTAATGAAAAGCGTTTTTACGATCGGATGATCCAGGTTGCCGATCGGGAATTCAC
GAACTGGCTGAACACATTAAACGAGAAGGAGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10016.38 Da        Isoelectric Point: 6.2267

>AT177902 WP_001301023.1 NZ_CP063332:c560770-560504 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDAKNASPES
TEQQNLEW

Download         Length: 267 bp

>AT177902 NZ_CP083754:c1857428-1857126 [Serratia marcescens]
ATGGGCAGAACGTTGGAACAGCTTATTGCGGATGAAAAGCCCGAGGTCGTGGCCAAAGCACAGGCGCTGGCGGCGGACAT
CATGCTGAACATTCACCTTGCCGAGCTGCGTGAAAAAGTACAGAAAACGCAGGTTGAAATGGCGCAGGCGCTGGGGATCA
GGCAGCCGACCGTTGCCGTGATGGAAAAACCGGGCCGCGATCTGAAACTGTCTTCGCTTAAACGCTATGTTGAGGCGGCC
GGCGGCAAACTGCGCCTGGACATCGAACTGCCGGACGGCTCTCACTACGAATTTGTGCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5K98
PDB 3TPV
PDB 3DNV
PDB 3TPD
PDB 3HZI
PDB 3FBR
PDB 4YG7
PDB 3TPE
PDB 2WIU
PDB 3DNT
PDB 3TPB
PDB 3TPT
PDB 3DNU

Antitoxin

Source ID Structure

References