Detailed information of TA system TA177898

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 2663110..2663855
• Replicon: chromosome
• Accession: NZ_CP063314
• Organism: Proteus vulgaris strain LC-693

Toxin (Protein)

• Gene name: tacT
• Uniprot ID: -
• Locus tag: IM703_RS11945
• Protein ID: WP_197269053.1
• Coordinates: 2663110..2663601 (-)
• Length: 164 a.a.

Antitoxin (Protein)

• Gene name: tacA
• Uniprot ID: -
• Locus tag: IM703_RS11950
• Protein ID: WP_075673024.1
• Coordinates: 2663589..2663855 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IM703_RS11925	2658185..2659291	+	1107	WP_072068523.1	flagellar basal body P-ring protein FlgI	-
IM703_RS11930	2659291..2660277	+	987	WP_197269052.1	flagellar assembly peptidoglycan hydrolase FlgJ	-
IM703_RS11935	2660395..2662047	+	1653	WP_196553711.1	flagellar hook-associated protein FlgK	-
IM703_RS11940	2662079..2663023	+	945	WP_196553710.1	flagellar hook-associated protein FlgL	-
IM703_RS11945	2663110..2663601	-	492	WP_197269053.1	GNAT family N-acetyltransferase	Toxin
IM703_RS11950	2663589..2663855	-	267	WP_075673024.1	DUF1778 domain-containing protein	Antitoxin
IM703_RS11955	2663979..2664761	-	783	WP_072068517.1	flagellar type III secretion system protein FliR	-
IM703_RS11960	2664767..2665036	-	270	WP_036935757.1	flagellar biosynthesis protein FliQ	-
IM703_RS11965	2665052..2665822	-	771	WP_072068515.1	flagellar type III secretion system pore protein FliP	-
IM703_RS11970	2665822..2666268	-	447	WP_072068514.1	flagellar biosynthetic protein FliO	-
IM703_RS11975	2666272..2666682	-	411	WP_006533153.1	flagellar motor switch protein FliN	-
IM703_RS11980	2666675..2667703	-	1029	WP_072068513.1	flagellar motor switch protein FliM	-
IM703_RS11985	2667709..2668191	-	483	WP_006533151.1	flagellar basal body-associated protein FliL	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (22-148)

Antitoxin

• Vibrio phage ICP1, Orf50 (2-87)

Sequences

Toxin

Protein

• Length: 164 a.a.
• Molecular weight: 18208.10 Da
• Isoelectric Point: 10.2217

>T177898 WP_197269053.1 NZ_CP063314:c2663601-2663110 [Proteus vulgaris]
MGKITAPEPLSNSHEVADFYSSENVLDNWIKQRGLKNQFLGASRTFVVCEKNKKRVVGYYSLATGSVNHTEAISHIRRNM
PDPIPVIVLARLAVDKTFHGKGLGADLLRDAVLRCHHVAENIGVRAIMVHALTENAKHFYLHHGFNASSIQDKILFLALK
KKI

Nucleotide

• Length: 492 bp

>T177898 NZ_CP083752:c135674-135231 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAACAGGCGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
TGGGCACGCTATCGCGGCCGGCGCCGTCCTAGTGACGAACAATGTGAGAGAGTTTGAGCGGGTGCCGGGTCTGGTGCTGG
AAGACTGGGTGAAGAAAGCCGCTCTCTGCAGGGTAATTTCTTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10111.62 Da
• Isoelectric Point: 4.5256

>AT177898 WP_075673024.1 NZ_CP063314:c2663855-2663589 [Proteus vulgaris]
MKADVQLNIRAKESQRALIDTAAEILHKSRTDFILETACQAAEDVILDRRTFNLNDAQYAEFIEIIDAPVDIDPALEKLL
MRKPLWEK

Nucleotide

• Length: 267 bp

>AT177898 NZ_CP083752:c135901-135671 [Klebsiella pneumoniae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGCTCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA