Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1453686..1454235 Replicon chromosome
Accession NZ_CP063314
Organism Proteus vulgaris strain LC-693

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag IM703_RS06640 Protein ID WP_196554567.1
Coordinates 1453930..1454235 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag IM703_RS06635 Protein ID WP_196554568.1
Coordinates 1453686..1453940 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IM703_RS06615 1448846..1449700 + 855 WP_197269816.1 4-hydroxybenzoate octaprenyltransferase -
IM703_RS06620 1449801..1452284 - 2484 WP_197269817.1 glycerol-3-phosphate 1-O-acyltransferase PlsB -
IM703_RS06625 1452415..1452786 + 372 WP_006536373.1 diacylglycerol kinase -
IM703_RS06630 1452914..1453525 + 612 WP_072070935.1 transcriptional repressor LexA -
IM703_RS06635 1453686..1453940 + 255 WP_196554568.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
IM703_RS06640 1453930..1454235 + 306 WP_196554567.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IM703_RS06645 1454269..1454799 - 531 WP_072070933.1 zinc uptake transcriptional repressor Zur -
IM703_RS06650 1455013..1455540 - 528 WP_088494417.1 single-stranded DNA-binding protein SSB1 -
IM703_RS06655 1455793..1458627 + 2835 WP_197269818.1 excinuclease ABC subunit UvrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-47)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11957.06 Da        Isoelectric Point: 10.2220

>T177897 WP_196554567.1 NZ_CP063314:1453930-1454235 [Proteus vulgaris]
MIFNLEFDKRALKEWRKLDQSIKEQFKKKLKKLQENPYIESARLKDDLAGCYKIKLRASGFRLVYQVIDSEVVILVIAVG
KREESKAYSLAEVRIQKNNMY

Download         Length: 306 bp

>T177897 NZ_CP083752:c70253-69771 [Klebsiella pneumoniae]
GTGGGACGTATAACCGCGCCCGAGCCGTTATCCAGCGCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCACTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGAAGGGTACGA
AGAAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCTACAGGCAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGTGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGCGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9780.23 Da        Isoelectric Point: 4.5749

>AT177897 WP_196554568.1 NZ_CP063314:1453686-1453940 [Proteus vulgaris]
MATIQVRVDDELKKEAYQVFEKMNLSPSDAIRLFLRYVSENEKLPFSEVSVVVGELDEDEDILAVVRERLKKPSKRIRVN
IDDL

Download         Length: 255 bp

>AT177897 NZ_CP083752:c70507-70241 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGTACTCATCGATGCCGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGATTCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References