Detailed information of TA system TA177895

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 260319..260931
• Replicon: chromosome
• Accession: NZ_CP063314
• Organism: Proteus vulgaris strain LC-693

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: A0A379EIK6
• Locus tag: IM703_RS01200
• Protein ID: WP_006535062.1
• Coordinates: 260728..260931 (+)
• Length: 68 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: -
• Locus tag: IM703_RS01195
• Protein ID: WP_196553556.1
• Coordinates: 260319..260681 (+)
• Length: 121 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IM703_RS01185	255330..256523	+	1194	WP_115350452.1	efflux RND transporter periplasmic adaptor subunit	-
IM703_RS01190	256538..259687	+	3150	WP_197269535.1	efflux RND transporter permease subunit	-
IM703_RS01195	260319..260681	+	363	WP_196553556.1	Hha toxicity modulator TomB	Antitoxin
IM703_RS01200	260728..260931	+	204	WP_006535062.1	hemolysin expression modulator Hha	Toxin
IM703_RS01210	261705..262577	+	873	WP_196553555.1	acyl-CoA thioesterase II	-
IM703_RS01215	262613..263905	-	1293	WP_197269536.1	ammonium transporter AmtB	-
IM703_RS01220	263918..264256	-	339	WP_072069375.1	P-II family nitrogen regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (8-64)

Antitoxin

• Biofilm formation regulator YbaJ (1-114)

Sequences

Toxin

Protein

• Length: 68 a.a.
• Molecular weight: 8061.34 Da
• Isoelectric Point: 6.9770

>T177895 WP_006535062.1 NZ_CP063314:260728-260931 [Proteus vulgaris]
MTKTDYLMRLRKCTSIETLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPASVWKFVR

Nucleotide

• Length: 204 bp

>T177895 NZ_CP083751:c5158429-5158046 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin

Protein

• Length: 121 a.a.
• Molecular weight: 13978.81 Da
• Isoelectric Point: 4.6017

>AT177895 WP_196553556.1 NZ_CP063314:260319-260681 [Proteus vulgaris]
MDEYSPEKVDLAELSFLCEELLQQALGSLDKGNTVWHNDLSSTKSVDLNVLIEHIMDFSWKFKIKHPDKQIINTLIEEYL
EETYRLFGNTSISYSDINNWKELNHSLLTLIANNPKSYIK

Nucleotide

• Length: 363 bp

>AT177895 NZ_CP083751:c5158671-5158429 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATACCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Structures

Toxin

• AlphaFold DB: A0A379EIK6