Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 2022368..2022868 Replicon chromosome
Accession NZ_CP063310
Organism Eggerthella sp. HF-1101

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag GS424_RS08360 Protein ID WP_160941856.1
Coordinates 2022368..2022622 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag GS424_RS08365 Protein ID WP_101722542.1
Coordinates 2022641..2022868 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GS424_RS08335 2017590..2018513 + 924 WP_160941586.1 GTPase Era -
GS424_RS08340 2018703..2020247 + 1545 WP_160941585.1 PASTA domain-containing protein -
GS424_RS08345 2020254..2021030 + 777 WP_160941584.1 DNA repair protein RecO -
GS424_RS08350 2021081..2021332 + 252 WP_160941583.1 TIGR03905 family TSCPD domain-containing protein -
GS424_RS08355 2021317..2022099 - 783 WP_160941582.1 C39 family peptidase -
GS424_RS08360 2022368..2022622 - 255 WP_160941856.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GS424_RS08365 2022641..2022868 - 228 WP_101722542.1 antitoxin Antitoxin
GS424_RS08370 2023006..2024112 - 1107 WP_160941581.1 hypothetical protein -
GS424_RS08375 2024138..2024815 - 678 WP_160941580.1 leucine-rich repeat domain-containing protein -
GS424_RS08380 2025084..2025782 + 699 WP_160941579.1 response regulator transcription factor -
GS424_RS08385 2025795..2026949 + 1155 WP_160941578.1 HAMP domain-containing histidine kinase -
GS424_RS08390 2026999..2027451 + 453 WP_160941577.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-81)

Antitoxin

Protein of unknown function DUF6290

(3-69)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9627.18 Da        Isoelectric Point: 10.6115

>T177893 WP_160941856.1 NZ_CP063310:c2022622-2022368 [Eggerthella sp. HF-1101]
MTSGAVKQLRSLDRKTLLLVSELIERLDGCENPCTLPNAKKLQGVKNGWRWRTGTYRVLGTVDGDRITIEVFKIGHRRDV
YRNL

Download         Length: 255 bp

>T177893 NZ_CP083751:c4677717-4677433 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8434.39 Da        Isoelectric Point: 4.1068

>AT177893 WP_101722542.1 NZ_CP063310:c2022868-2022641 [Eggerthella sp. HF-1101]
MAMTASAIRFEPNEKEWIAAFAEMNGSTFSAQVRQWTLERLEDELDARDLSQAIEEDDGTRISWSKAKADLGLAI

Download         Length: 228 bp

>AT177893 NZ_CP083751:c4677949-4677707 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCTGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References