Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 2959653..2960299 Replicon chromosome
Accession NZ_CP063303
Organism Yersinia pestis strain 14D

Toxin (Protein)


Gene name hicA Uniprot ID A0A3G5L3F2
Locus tag IM067_RS12990 Protein ID WP_002214976.1
Coordinates 2959653..2959835 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0U1R391
Locus tag IM067_RS12995 Protein ID WP_002211129.1
Coordinates 2959880..2960299 (+) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IM067_RS12955 (IM067_12935) 2955039..2955509 + 471 WP_002227961.1 flagellar basal body-associated protein FliL -
IM067_RS12960 (IM067_12940) 2955515..2956516 + 1002 WP_002211135.1 flagellar motor switch protein FliM -
IM067_RS12965 (IM067_12945) 2956513..2956929 + 417 WP_002211134.1 flagellar motor switch protein FliN -
IM067_RS12970 (IM067_12950) 2956929..2957465 + 537 WP_002211133.1 flagellar biosynthetic protein FliO -
IM067_RS12975 (IM067_12955) 2957546..2958286 + 741 WP_002220494.1 flagellar type III secretion system pore protein FliP -
IM067_RS12980 (IM067_12960) 2958392..2958661 + 270 WP_002211131.1 flagellar biosynthesis protein FliQ -
IM067_RS12985 (IM067_12965) 2958664..2959446 + 783 WP_002211130.1 flagellar biosynthetic protein FliR -
IM067_RS12990 (IM067_12970) 2959653..2959835 + 183 WP_002214976.1 type II toxin-antitoxin system HicA family toxin Toxin
IM067_RS12995 (IM067_12975) 2959880..2960299 + 420 WP_002211129.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
IM067_RS13000 (IM067_12980) 2960557..2961516 - 960 WP_002223882.1 sugar kinase -
IM067_RS13005 (IM067_12985) 2961565..2962587 - 1023 WP_002214974.1 ABC transporter permease -
IM067_RS13010 (IM067_12990) 2962590..2964167 - 1578 WP_002211126.1 sugar ABC transporter ATP-binding protein -
IM067_RS13015 (IM067_12995) 2964233..2965228 - 996 WP_002211125.1 substrate-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-131)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6783.99 Da        Isoelectric Point: 10.8877

>T177883 WP_002214976.1 NZ_CP063303:2959653-2959835 [Yersinia pestis]
VKSSELIKLLETNGWKLMRVKGSHHQFKHPDFAAVITVPHPKKDVKPGTLRQILKDANLS

Download         Length: 183 bp

>T177883 NZ_CP083749:c375441-374704 [Bacillus sp. CRB-7]
GTGATCTCTAACATTCGAATCGGCTTATTTATTTTAGTAATCGTTTTTCTAGTACTTGTTTTCTGTTATTGGAAAAACGA
AGAGTTGTACGAGGAGAAGAAGCAACGTATTAGAAAGACTTGGTATGGGTTGTTTATAATATCAGTCACCGTGTATTTCA
TGATAAAAGGAATTGATTTAACCCTCTGGAAAAATCTTTTAATGTTCACTGCAATGGTTATTTTCGTTGATATTGCATTT
ATTTTAACACCGAATATTTCAGAAATATGGGGAGCGAAATTTAGCGATATCGGCAAGACGGTTCAATCGATAAAACGGTC
ATTAATTGCTTCTAAAGCAAGAGGAGAAATATACACAACAATCATTCAAAATGTAAATCCAGCAGTGTTCGGTACGATGG
AATGGCATACGGAGGAAGAATATACAAAAAGCTTAAACGCATTTTTAGATTCGTATGGGGAAAAGATTGGAGCAAAAATT
GTTGTATTTGAAGCGGCAAAGGAATTAAATACAAACTTTCGTGGTATACGTTCTCAATTTAGTACTATGATTCCGTTAGA
GTACATTGAGCAATTGAATGAGCAGAGAGCAGTACAAGTAGAAAATGTCGGAATTATACCAGCAAAAATAGTGAGTGATG
TTTTCATTGTTATTGATGGGAAGAAAAATAACCTGCAAGATCGAGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15549.42 Da        Isoelectric Point: 4.7731

>AT177883 WP_002211129.1 NZ_CP063303:2959880-2960299 [Yersinia pestis]
MAIYPAYVHVDNDGSASGYFPDVKGCIFAINAGEDLFAEASSALDAHFEALVSEGIEIPEAHDMPYHVYRNPCDYADGGQ
WYNVNIDMSKYDGKVERINVTLPHRLIHQIDTIVKVRPEYASRSNFLAEAARKELQKLA

Download         Length: 420 bp

>AT177883 NZ_CP083749:c374591-374466 [Bacillus sp. CRB-7]
GTGATAAAAAATAATGACAATGATTTTTTTAAAGAAGATAATGAAGATACAACGGATTTCTCGTTAATTAAAGGGGATAC
GATGCAGCAAGTAGAAGAATTAGAAGATGAATTAAAAAGAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G5L3F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0U1R391

References