Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /COG5642-COG5654 |
| Location | 2394484..2395450 | Replicon | chromosome |
| Accession | NZ_CP063303 | ||
| Organism | Yersinia pestis strain 14D | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | A0A0E8XJV6 |
| Locus tag | IM067_RS10385 | Protein ID | WP_002210981.1 |
| Coordinates | 2394484..2394942 (-) | Length | 153 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | Q66A69 |
| Locus tag | IM067_RS10390 | Protein ID | WP_002210982.1 |
| Coordinates | 2395004..2395450 (-) | Length | 149 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| IM067_RS10355 (IM067_10335) | 2390298..2390963 | + | 666 | WP_002210975.1 | phage shock protein PspA | - |
| IM067_RS10360 (IM067_10340) | 2391125..2391352 | + | 228 | WP_002210976.1 | envelope stress response membrane protein PspB | - |
| IM067_RS10365 (IM067_10345) | 2391352..2391711 | + | 360 | WP_002210977.1 | envelope stress response membrane protein PspC | - |
| IM067_RS10370 (IM067_10350) | 2391796..2392038 | + | 243 | WP_002216375.1 | phage shock protein PspD | - |
| IM067_RS10375 (IM067_10355) | 2392019..2393416 | + | 1398 | WP_002210979.1 | YcjX family protein | - |
| IM067_RS10380 (IM067_10360) | 2393413..2394474 | + | 1062 | WP_002210980.1 | YcjF family protein | - |
| IM067_RS10385 (IM067_10365) | 2394484..2394942 | - | 459 | WP_002210981.1 | RES family NAD+ phosphorylase | Toxin |
| IM067_RS10390 (IM067_10370) | 2395004..2395450 | - | 447 | WP_002210982.1 | DUF2384 domain-containing protein | Antitoxin |
| IM067_RS10395 (IM067_10375) | 2395786..2397363 | + | 1578 | WP_002210983.1 | transcriptional regulator TyrR | - |
| IM067_RS10400 (IM067_10380) | 2397510..2397968 | - | 459 | WP_002213775.1 | IS200/IS605-like element IS1541B family transposase | - |
| IM067_RS10405 (IM067_10385) | 2398221..2398724 | - | 504 | WP_002210984.1 | thiol peroxidase | - |
| IM067_RS10410 (IM067_10390) | 2398887..2399861 | + | 975 | WP_002210985.1 | L-Ala-D/L-Glu epimerase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 2397510..2397968 | 458 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 153 a.a. Molecular weight: 16994.38 Da Isoelectric Point: 4.8732
>T177882 WP_002210981.1 NZ_CP063303:c2394942-2394484 [Yersinia pestis]
MTLYRIVMRRYLASAWTGYGAEIYGGRWNHKGHAAIYLASSISLAMLETLAHIQDSSTLSEFELFQIEISDSSIMLLQPQ
DWPTDWRSDPAPVATMDVGTEWLESESSVGLLVPSTLVPSENNLLVNPHHKDFPACLASVKPLSFVFDPRLK
MTLYRIVMRRYLASAWTGYGAEIYGGRWNHKGHAAIYLASSISLAMLETLAHIQDSSTLSEFELFQIEISDSSIMLLQPQ
DWPTDWRSDPAPVATMDVGTEWLESESSVGLLVPSTLVPSENNLLVNPHHKDFPACLASVKPLSFVFDPRLK
Download Length: 459 bp
>T177882 NZ_CP083747:c330986-330609 [Pseudomonas sp. p1(2021b)]
ATGACAAACAAAGAAAAACCGCTCGAATGGATCGCGAGCAGCCACAAGGATTTGATGGCGTTGCCGTCCGACGTGCGTCG
CCGTTTCGGTTACGCGCTCTCGTTGGCGCAGATAGGCGATCAGGATGACGCAGCAAAGGTGCTCAAGGGGTTCGGTGGTG
CCGGCGTGCTGGAGGTCGTCGAAGACGATGCCGGCGGCACCTATCGAGCGGTATACACGGTCAAGTTTGCGGAAGCGGTG
TTCGTCCTGCACTGCTTCCAGAAGAAGAGCAAGAGCGGAATCGCCACGCCAAAGGCCGACATGGACATCATCCGCGCTCG
GCTGAAGGTGGCCGAGGTATTGGCACAGGAGCTACGAAATGCAAAAACGAATCATTGA
ATGACAAACAAAGAAAAACCGCTCGAATGGATCGCGAGCAGCCACAAGGATTTGATGGCGTTGCCGTCCGACGTGCGTCG
CCGTTTCGGTTACGCGCTCTCGTTGGCGCAGATAGGCGATCAGGATGACGCAGCAAAGGTGCTCAAGGGGTTCGGTGGTG
CCGGCGTGCTGGAGGTCGTCGAAGACGATGCCGGCGGCACCTATCGAGCGGTATACACGGTCAAGTTTGCGGAAGCGGTG
TTCGTCCTGCACTGCTTCCAGAAGAAGAGCAAGAGCGGAATCGCCACGCCAAAGGCCGACATGGACATCATCCGCGCTCG
GCTGAAGGTGGCCGAGGTATTGGCACAGGAGCTACGAAATGCAAAAACGAATCATTGA
Antitoxin
Download Length: 149 a.a. Molecular weight: 16401.94 Da Isoelectric Point: 9.7155
>AT177882 WP_002210982.1 NZ_CP063303:c2395450-2395004 [Yersinia pestis]
MRAYRPNPATKMGTLWREIGLPASRGTILVDSIKMGFSVDVIDSIHLWASMPKAEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAITWMSTPIKGLGYRSPDSLLETETGALEVCDLIGRLEHGVFT
MRAYRPNPATKMGTLWREIGLPASRGTILVDSIKMGFSVDVIDSIHLWASMPKAEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAITWMSTPIKGLGYRSPDSLLETETGALEVCDLIGRLEHGVFT
Download Length: 447 bp
>AT177882 NZ_CP083747:c330628-330293 [Pseudomonas sp. p1(2021b)]
ATGCAAAAACGAATCATTGAAGGCGTCGAGGTTCAGCGCAGCTCGGGCAACGTCTTTGCCGACCTTGGACTGCCTGACGC
TGAAAAGCTCAAGATCAAGACCGGCCTGGTGGTCGAGATCAGGAGGGCCATGCGCGCCCTTGGGCTGACTCAACAAGCGG
CGGCCAAACGCATGGGCATCCCGCAACCGAAGGTGTCGGGCATGATGCGCGGCGACTTCACCAATCTATCCGAACGCAAG
CTGATGGATTGTCTGAATCGCCTCGGCTACGACATCGAAATCAAGGTACGGCCAGCAGCCGAGCCGATCGGGCATCTAAC
GCTCGCAACCGCTTAA
ATGCAAAAACGAATCATTGAAGGCGTCGAGGTTCAGCGCAGCTCGGGCAACGTCTTTGCCGACCTTGGACTGCCTGACGC
TGAAAAGCTCAAGATCAAGACCGGCCTGGTGGTCGAGATCAGGAGGGCCATGCGCGCCCTTGGGCTGACTCAACAAGCGG
CGGCCAAACGCATGGGCATCCCGCAACCGAAGGTGTCGGGCATGATGCGCGGCGACTTCACCAATCTATCCGAACGCAAG
CTGATGGATTGTCTGAATCGCCTCGGCTACGACATCGAAATCAAGGTACGGCCAGCAGCCGAGCCGATCGGGCATCTAAC
GCTCGCAACCGCTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E8XJV6 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E8XFL1 |