Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 901454..902126 Replicon chromosome
Accession NZ_CP063303
Organism Yersinia pestis strain 14D

Toxin (Protein)


Gene name cptA Uniprot ID Q666S4
Locus tag IM067_RS03720 Protein ID WP_002215144.1
Coordinates 901701..902126 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID Q666S3
Locus tag IM067_RS03715 Protein ID WP_002209939.1
Coordinates 901454..901720 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IM067_RS03695 (IM067_03700) 897311..898414 + 1104 WP_002209943.1 hypothetical protein -
IM067_RS03700 (IM067_03705) 898616..899317 + 702 WP_002209942.1 hemolysin III family protein -
IM067_RS03705 (IM067_03710) 899575..900072 + 498 WP_002209941.1 DUF2165 family protein -
IM067_RS03710 (IM067_03715) 900145..901137 - 993 WP_002209940.1 tRNA-modifying protein YgfZ -
IM067_RS03715 (IM067_03720) 901454..901720 + 267 WP_002209939.1 FAD assembly factor SdhE Antitoxin
IM067_RS03720 (IM067_03725) 901701..902126 + 426 WP_002215144.1 protein YgfX Toxin
IM067_RS03725 (IM067_03730) 902126..902824 + 699 WP_002209937.1 two-component system response regulator CreB -
IM067_RS03730 (IM067_03735) 902849..904267 + 1419 WP_002209936.1 two-component system sensor histidine kinase CreC -
IM067_RS03735 (IM067_03740) 904388..905845 + 1458 WP_002220113.1 cell envelope integrity protein CreD -
IM067_RS03740 (IM067_03745) 905935..906453 - 519 WP_002209934.1 flavodoxin FldB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-133)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 16510.43 Da        Isoelectric Point: 10.3799

>T177880 WP_002215144.1 NZ_CP063303:901701-902126 [Yersinia pestis]
VAQWRCNLRVSWHTQLFSLLAHGILVILTLVAPWPLGYTALWLVLLTLVVFECIRSQKRIKSCQGEIRLKPGNLVRWKRH
EWTVVKPPWITRYGVLLHLQQTGGHATRKRLWLSADSMSEDEWRQLCLLLRHSFESDDGTM

Download         Length: 426 bp

>T177880 NZ_CP063303:901701-902126 [Yersinia pestis]
GTGGCCCAGTGGCGATGTAACCTGCGGGTATCCTGGCATACTCAACTCTTTTCTTTATTGGCACACGGCATATTGGTCAT
TTTAACCTTGGTCGCGCCCTGGCCCTTGGGTTATACCGCCCTATGGCTGGTATTGCTGACGTTAGTGGTGTTTGAGTGTA
TCCGCAGCCAGAAAAGGATTAAATCCTGTCAGGGGGAAATCAGGCTAAAACCTGGCAACCTGGTGCGATGGAAAAGGCAT
GAATGGACCGTGGTCAAGCCGCCGTGGATCACCCGCTATGGGGTATTATTACATTTACAACAAACAGGCGGCCACGCGAC
CCGAAAGCGTCTATGGCTGTCCGCTGACAGCATGTCTGAAGATGAGTGGCGGCAGCTATGCCTGTTGCTGCGGCATTCAT
TTGAATCTGACGATGGAACGATGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10511.98 Da        Isoelectric Point: 4.6533

>AT177880 WP_002209939.1 NZ_CP063303:901454-901720 [Yersinia pestis]
MEIDNKARIHWACRRGMRELDISIMPFFEYEYDSLSDNEKQAFIRLLECDDPDLFNWLMNHGEPQDSELYQMVKLIQSRN
KARGPVAM

Download         Length: 267 bp

>AT177880 NZ_CP063303:901454-901720 [Yersinia pestis]
ATGGAAATTGATAATAAAGCCCGTATTCACTGGGCATGCCGCCGTGGTATGCGTGAACTTGATATCTCCATCATGCCGTT
TTTTGAATATGAATATGATAGCTTGAGCGATAACGAGAAACAGGCATTTATCCGCTTGCTTGAGTGTGATGACCCAGATT
TATTCAACTGGCTGATGAACCACGGGGAGCCGCAGGATAGCGAGCTATATCAGATGGTCAAACTGATTCAATCACGAAAT
AAAGCCCGTGGCCCAGTGGCGATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q666S4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8XP12

References