Detailed information of TA system TA177879

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX(toxin)
• Location: 4928224..4929043
• Replicon: chromosome
• Accession: NZ_CP063301
• Organism: Klebsiella grimontii strain M5a1

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: A0A9E1D5M6
• Locus tag: INR80_RS23355
• Protein ID: WP_004132607.1
• Coordinates: 4928786..4929043 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: A0A9E1DGJ5
• Locus tag: INR80_RS23350
• Protein ID: WP_004132606.1
• Coordinates: 4928224..4928775 (-)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
INR80_RS23335	4923613..4925010	+	1398	WP_004132593.1	MFS transporter	-
INR80_RS23340	4925134..4926474	+	1341	WP_049088521.1	carbohydrate porin	-
INR80_RS23345	4926578..4928206	-	1629	WP_064371487.1	SAM-dependent methyltransferase	-
INR80_RS23350	4928224..4928775	-	552	WP_004132606.1	N-acetyltransferase	Antitoxin
INR80_RS23355	4928786..4929043	-	258	WP_004132607.1	YjhX family toxin	Toxin
INR80_RS23360	4929627..4930811	+	1185	WP_004132609.1	mannonate dehydratase	-
INR80_RS23365	4930888..4932363	+	1476	WP_004132611.1	fructuronate reductase	-
INR80_RS23370	4932500..4933276	+	777	WP_004132612.1	Uxu operon transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (34-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9538.04 Da
• Isoelectric Point: 11.1381

>T177879 WP_004132607.1 NZ_CP063301:c4929043-4928786 [Klebsiella grimontii]
MNLSRQEQRTLHVLAKGGRIAHVRDASGRVTSVECYSREGLLLSDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T177879 NZ_CP083746:c2032436-2032254 [Pseudomonas sp. p1(2021b)]
GTGCAAAGCAGGCAGTTGATCAAGGAGCTTGAAGCCGCTGGATGGGTTCTGAAACGAGTCACCGGAAGCCACCACATCTT
CAAACACCCCAACAACCCAAACTCGATACCAGTGCCACACCCCAAGAAAGACCTACCGATCGGCACGGTAAAGAGCATCA
AGGAACGAGCCGGGTTGAAATGA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 19990.89 Da
• Isoelectric Point: 7.2343

>AT177879 WP_004132606.1 NZ_CP063301:c4928775-4928224 [Klebsiella grimontii]
MTNHSFTFHVASEGDTNDILHVETRAFGYSKEARLVADLLNDESACPTLSLLARHNGKAVGHILFTRATFKGEPDSPMMH
ILAPLAVVPEYQGAGVGGGLIRHGIEQLKAMGSQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEALKACWMLQPLSS
QPLGRTGQIQCARALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT177879 NZ_CP083746:c2032216-2031815 [Pseudomonas sp. p1(2021b)]
ATGCAATACCCAATCTGCATCGAGTGGGGCGACGAGAACACCGCCATCGGCATCCAGATCCCTGACATTCCAGGCGCCGT
GACCGCTGGAGACACGTTCGAGGAGGCCTACGCGGCAGCCGTCGAGGTTGCCCACATCATGCTGGAAGAGATCGCCGGCA
GCGGCCAGGCCATTCCCATGCCATCCAGCGCAGCGGCGCACCGTGGCAATCCCGACTTCGCGGATATGGGCTGGGGCATG
CTGGAGATCGACATAACCCCATACCTGGGCAAGACCGAGAAGGTCAATGTCACCCTGCCCGGCTTCGTCATCCAGCAGAT
CGACCGCTATGTCCGGGATCACAACGTGAAAAGCCGTTCCTCGTTCCTGGCTGATGCCGCCATGGAAAAACTGGGACGGT
AG