177865

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 226514..227124 Replicon chromosome
Accession NZ_CP063301
Organism Klebsiella grimontii strain M5a1

Toxin (Protein)


Gene name vapC Uniprot ID A0A9E1GAR7
Locus tag INR80_RS01085 Protein ID WP_049086919.1
Coordinates 226514..226888 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag INR80_RS01090 Protein ID WP_077265771.1
Coordinates 226885..227124 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INR80_RS01070 223669..224571 + 903 WP_004122548.1 formate dehydrogenase subunit beta -
INR80_RS01075 224568..225203 + 636 WP_004132860.1 formate dehydrogenase cytochrome b556 subunit -
INR80_RS01080 225547..226476 + 930 WP_004132861.1 formate dehydrogenase accessory protein FdhE -
INR80_RS01085 226514..226888 - 375 WP_049086919.1 type II toxin-antitoxin system VapC family toxin Toxin
INR80_RS01090 226885..227124 - 240 WP_077265771.1 ribbon-helix-helix domain-containing protein Antitoxin
INR80_RS01095 227330..228247 + 918 WP_024360706.1 alpha/beta hydrolase -
INR80_RS01100 228265..229206 - 942 WP_004127112.1 fatty acid biosynthesis protein FabY -
INR80_RS01105 229251..229688 - 438 WP_004132870.1 D-tyrosyl-tRNA(Tyr) deacylase -
INR80_RS01110 229685..230545 - 861 WP_004127107.1 virulence factor BrkB family protein -
INR80_RS01115 230539..231138 - 600 WP_004132872.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-110)

Antitoxin

Ribbon-helix-helix protein, CopG

(13-47)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14111.45 Da        Isoelectric Point: 8.4571

>T177865 WP_049086919.1 NZ_CP063301:c226888-226514 [Klebsiella grimontii]
MIKGPALFDTNILIDLFSGRVEAKQVLEAYPPQNAISLITWMEVMVGAKKYHQEHRTRIALSAFNIIDISQDIAERSVNL
RKEYGMKLPDAIILATAQIHRYELVTRNTKDFFGIPGVITPYHL

Download         Length: 375 bp

>T177865 NZ_CP083731:c4659006-4658695 [Salmonella sp. A29-2]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGAGGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGATCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9307.51 Da        Isoelectric Point: 4.3253

>AT177865 WP_077265771.1 NZ_CP063301:c227124-226885 [Klebsiella grimontii]
MMTGTNMGRILLDLSDDVIKRLEDLKQQRNLPRAELLREAVEQYLERQADTTISNALGIWQGCEEEGVEFERKLREEWQ

Download         Length: 240 bp

>AT177865 NZ_CP083731:c4658694-4658404 [Salmonella sp. A29-2]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTAAGCCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAAC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGCTCACCGACAGGGCCAGCCAAAGCATTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References