Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 5061189..5061705 Replicon chromosome
Accession NZ_CP063277
Organism Klebsiella pneumoniae strain MAR14-456

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag IL253_RS24630 Protein ID WP_004178374.1
Coordinates 5061189..5061473 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag IL253_RS24635 Protein ID WP_002886901.1
Coordinates 5061463..5061705 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IL253_RS24605 5056585..5056893 - 309 WP_012737232.1 PTS sugar transporter subunit IIB -
IL253_RS24610 5056978..5057151 + 174 WP_041169004.1 hypothetical protein -
IL253_RS24615 5057154..5057897 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
IL253_RS24620 5058254..5060392 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
IL253_RS24625 5060721..5061185 + 465 WP_004222151.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
IL253_RS24630 5061189..5061473 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IL253_RS24635 5061463..5061705 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
IL253_RS24640 5061783..5063693 - 1911 WP_012737231.1 BglG family transcription antiterminator -
IL253_RS24645 5063716..5064870 - 1155 WP_012737230.1 lactonase family protein -
IL253_RS24650 5064937..5065677 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T177859 WP_004178374.1 NZ_CP063277:c5061473-5061189 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T177859 NZ_CP083731:2407996-2408280 [Salmonella sp. A29-2]
ATGACTTATAAGCTGGCATTTAACGAATCAGCACTAAAAGAGTGGAAAAAACTGGGTCATACCATACAGGAACAGTTTAA
AAAAAAGCTAAGGGAACGGCTTGAAAACCCTCGGGTTCCGGCTTCTCAATTACATGGAAGAAAGGATCAGTACAAAATTA
AGCTGCGTGGTGCAGGATACAGACTGGTGTACAGCGTCGAAGATGAAATTATCACGGTAACTGTCATTGGTGTTGGAAAG
CGTGAAAATGATGCCGTCTACAAAGTGACACGACACAGAAGCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT177859 WP_002886901.1 NZ_CP063277:c5061705-5061463 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT177859 NZ_CP083731:2407758-2408006 [Salmonella sp. A29-2]
ATGGCATTTCAAATTTTAACGACTACTGCAGCAAGCATTACAGAACTGAAACGTGACCCAATGGGAACTTTCAATGCCGG
AGATGGCGCTCCAGTTGCCATTCTTAACCGTAATGAACCGGCTTTCTACTGTGTGCCTCCGGCACTTTATGCTCATCTTA
TGGATATTCTTGAGGATGAAGAACTCGGTCGTATTATCGATGAGCGTGCGAATGAACGCGTCATTGAGGTCAACATTGAT
GACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References