Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 964469..965126 Replicon chromosome
Accession NZ_CP063277
Organism Klebsiella pneumoniae strain MAR14-456

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag IL253_RS04755 Protein ID WP_002916310.1
Coordinates 964716..965126 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag IL253_RS04750 Protein ID WP_002916312.1
Coordinates 964469..964735 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IL253_RS04725 959671..961104 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
IL253_RS04730 961223..961951 - 729 WP_048336809.1 MurR/RpiR family transcriptional regulator -
IL253_RS04735 962001..962318 + 318 WP_077274463.1 N(4)-acetylcytidine aminohydrolase -
IL253_RS04740 962482..963141 + 660 WP_002916317.1 hemolysin III family protein -
IL253_RS04745 963240..964223 - 984 WP_014906951.1 tRNA-modifying protein YgfZ -
IL253_RS04750 964469..964735 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
IL253_RS04755 964716..965126 + 411 WP_002916310.1 protein YgfX Toxin
IL253_RS04760 965133..965654 - 522 WP_002916308.1 flavodoxin FldB -
IL253_RS04765 965755..966651 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
IL253_RS04770 966674..967387 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
IL253_RS04775 967393..969126 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T177847 WP_002916310.1 NZ_CP063277:964716-965126 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T177847 NZ_CP083728:1212717-1212905 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT177847 WP_002916312.1 NZ_CP063277:964469-964735 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT177847 NZ_CP083728:1212428-1212688 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References