Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1257124..1258040 Replicon chromosome
Accession NZ_CP063276
Organism Bacillus mojavensis strain LDFZ001

Toxin (Protein)


Gene name spoIISA Uniprot ID A0A7G7U9Y2
Locus tag IM743_RS06475 Protein ID WP_024121091.1
Coordinates 1257294..1258040 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID A0A7G7U9Y3
Locus tag IM743_RS06470 Protein ID WP_024121090.1
Coordinates 1257124..1257294 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IM743_RS06435 1253987..1254316 + 330 WP_106020448.1 XkdW family protein -
IM743_RS06440 1254313..1254477 + 165 WP_193660423.1 XkdX family protein -
IM743_RS06445 1254521..1255360 + 840 WP_193660424.1 phage portal protein -
IM743_RS06450 1255416..1255685 + 270 WP_059292937.1 hemolysin XhlA family protein -
IM743_RS06455 1255697..1255960 + 264 WP_059352788.1 phage holin -
IM743_RS06460 1255973..1256866 + 894 WP_059336101.1 N-acetylmuramoyl-L-alanine amidase -
IM743_RS06465 1256903..1257040 - 138 WP_125825426.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISC -
IM743_RS06470 1257124..1257294 - 171 WP_024121090.1 type II toxin-antitoxin system SpoIISB family antitoxin Antitoxin
IM743_RS06475 1257294..1258040 - 747 WP_024121091.1 toxin-antitoxin-antitoxin system toxin SpoIISA Toxin
IM743_RS06480 1258150..1259151 - 1002 WP_193660425.1 inorganic phosphate transporter -
IM743_RS06485 1259164..1259781 - 618 WP_193660426.1 DUF47 domain-containing protein -
IM743_RS06490 1260057..1261373 - 1317 WP_193660427.1 serine/threonine exchanger -
IM743_RS06495 1261768..1262718 + 951 WP_193660428.1 ring-cleaving dioxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-238)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29076.48 Da        Isoelectric Point: 4.4986

>T177843 WP_024121091.1 NZ_CP063276:c1258040-1257294 [Bacillus mojavensis]
MLLFFQIMVWCTMAALGLYVYATWRFEAKVKEKMSAIRKTWYLLFVLGAMIYWTYDPSSLFTNWERYVIVAVSFALIDAF
IFLSAYVKKLAGSELETDTREILEENNEMLHMYLDRLKTYQYLLKNEPIHVYYGSIEAYAEGIDKLLKTYADKMNLTASL
CHYSTQSDKDRLTEHMEDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQSYVIKLTSDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGEG

Download         Length: 747 bp

>T177843 NZ_CP083721:c1024184-1023888 [Bradyrhizobium sp. 41S5]
GTGAAGCTCGTCTGGACGCGCTTCGCACTGTCCGATCGCGACGACATTTTCAGCTACATCGAGGCCGAGAATCCCCGTGC
CGCGGTTCATGTCGATGAACAGATCGCCGATGCCGCGCGGCGCCTGCTCGACTTTCCTGACAGTGGCCGGCCCGGGCGTG
TCGCCGGCACGCGGGAGTTAGTCATCCCGCGCACACCTTATGTCGCAGCGTACCTTGTCGACGGCGAGACCGTTCGCATC
TTGCGCGTGCTTCACGGCGCGCAGATGTGGCCCGACGAACTTGCAAATGACGATTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6578.62 Da        Isoelectric Point: 10.9236

>AT177843 WP_024121090.1 NZ_CP063276:c1257294-1257124 [Bacillus mojavensis]
MENAFQNGCHPRAKKPFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA

Download         Length: 171 bp

>AT177843 NZ_CP083721:c1024489-1024181 [Bradyrhizobium sp. 41S5]
ATGGCTTCGAATGCCCTGGTCCAAACCCGCATCGATGCGGACGTAAAAGAGAAGGCCACCGCGGTTCTGGAAAACATGGG
TCTCACGGTGTCGGACGCGGTGCGGATATTGCTGACGCGCACGGCCAATGAAGGGACGCTTCCACTGGAGCTCGTCAGCA
ACAGCCAAGCTTACGACAGCTGGTTTCGCGAGAAGGTGCGCCAAGCGCTGGCGGATACACGGCCCAGTCTCGATGATTCC
GAAGTCGACGCGCATTTCGCGCAACGTCGTGCCGCCGCACTTCGAAAAGCGGCGGAACGCAAACGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7G7U9Y2

Antitoxin

Source ID Structure
AlphaFold DB A0A7G7U9Y3

References