Detailed information of TA system TA177841

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 4862618..4864203
• Replicon: chromosome
• Accession: NZ_CP063242
• Organism: Pectobacterium carotovorum strain XP-13

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: IHJ55_RS21555
• Protein ID: WP_161510020.1
• Coordinates: 4862884..4864203 (+)
• Length: 440 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: IHJ55_RS21550
• Protein ID: WP_039475230.1
• Coordinates: 4862618..4862884 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IHJ55_RS21525	4858252..4859754	-	1503	WP_201880203.1	MFS transporter	-
IHJ55_RS21530	4859858..4860412	+	555	WP_010302412.1	TetR/AcrR family transcriptional regulator	-
IHJ55_RS21535	4860462..4860872	-	411	WP_161510016.1	helix-turn-helix transcriptional regulator	-
IHJ55_RS21540	4860986..4861837	+	852	WP_039475225.1	SDR family oxidoreductase	-
IHJ55_RS21545	4861894..4862457	-	564	WP_203470601.1	hypothetical protein	-
IHJ55_RS21550	4862618..4862884	+	267	WP_039475230.1	helix-turn-helix domain-containing protein	Antitoxin
IHJ55_RS21555	4862884..4864203	+	1320	WP_161510020.1	type II toxin-antitoxin system HipA family toxin	Toxin
IHJ55_RS21560	4864236..4865600	-	1365	WP_010302387.1	tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE	-
IHJ55_RS21565	4865729..4867363	-	1635	WP_010281240.1	membrane protein insertase YidC	-
IHJ55_RS21570	4867366..4867623	-	258	WP_010281237.1	membrane protein insertion efficiency factor YidD	-
IHJ55_RS21575	4867587..4867946	-	360	WP_010302382.1	ribonuclease P protein component	-
IHJ55_RS21580	4867965..4868105	-	141	WP_005976668.1	50S ribosomal protein L34	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (150-401)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 440 a.a.
• Molecular weight: 49269.42 Da
• Isoelectric Point: 6.6183

>T177841 WP_161510020.1 NZ_CP063242:4862884-4864203 [Pectobacterium carotovorum]
MAALDVYMNGYRVGILTKTGSGAHHFSYDANWLGLPGSRPISLSMPLRHQPYQGDEVYNFFDNLLPDNPDIRRRIVARHH
ADSTQPFDLLAKVGQDSVGALQLVPQGTPVHDIKKIEYKTLSEQQLENILTGYLSDAPLGMIDTEDDFRISIAGAQEKTA
LLYLDDHWCLPLNATPTTHIIKLPIGKIESHSYSIDMSDSVENEYLCLLIAKAFGLPVPHCFMINAGKIKALAVERFDRK
YASDVSWIMRLPQEDFCQVLNVPSALKYENHGGPGISAIMSFLLGSVDPERDRYRFMQAQVLFWLLAATDGHAKNFSLFI
ESEGRYRLTPFYDILSMYPAMGGRGTDRREAKLAMGLTGSRGKKYAIEQIFPRHFFQTAKAVGFARESMENILVEFSNTV
ETVMTTVGSQLPVDFPTHISEAILAGLQARSRRLMRGWE

Nucleotide

• Length: 1320 bp

>T177841 NZ_CP083718:2351998-2352282 [Cupriavidus metallidurans]
ATGATCCGCTCGCTCTCCGACAAGACAACGGCCGCCATCTATTGCGGCCAGTCCGTTCACACACTGCCCGCTCACATTCA
GGCCGACGCGCTGCGCAAGCTCGCGATCCTCGACGCTGCGTCGTCTCTTCCCGATATGGTCGCCCCACCCGCAAACCGGC
TGGAACCAGTTCTTGGCAAGCGCCGCGGACACTGGCGCGTCCGCATTAAAGGTCCGTGGCATCTCTGTTTTCGCTTCATC
AACGGCGAAGCCTGGGACGTCGGCATCGCCGAATACGAGGAATAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9917.18 Da
• Isoelectric Point: 9.7281

>AT177841 WP_039475230.1 NZ_CP063242:4862618-4862884 [Pectobacterium carotovorum]
MKVTNSKQLSSYLKDVRITQKLSQGKVASKVGIRQDTVSSFEQHPDSTKLETFFKILSALNLELTVTPRNVDTTNNEASV
ASSWKEEW

Nucleotide

• Length: 267 bp

>AT177841 NZ_CP083718:2352292-2352639 [Cupriavidus metallidurans]
ATGACAATCAACCGCGAAGACTTGCGGCGCGCGGATTTTCGCAGCATTGCCACCGGCCAGCCGATTCCGCCGGCACACCC
CGGCGATGTACTGGAAACCGAGTTCATGGCGCCAAACGAACTGTCGGCGGAAGCATTGGCGGTGGCCTTGCATATGGCGC
CGCAACGAATTCACGATATCGTGCGGCGTCAGCGAGCCATCTCGCCAGACACCGCCCTGCGGCTGGCCCGCTATTTCGGC
ACTAGTGCGGAATTCTGGGCGGGCCTCCAGACCGCATATGCACTGCGGCTGGCGCGCGCGACTGCAGGGGCGAACATCGA
GCGCGACATCCAGCCGCTGACAGCATGA