Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 4663275..4663882 Replicon chromosome
Accession NZ_CP063242
Organism Pectobacterium carotovorum strain XP-13

Toxin (Protein)


Gene name doc Uniprot ID A0A7V8T7U1
Locus tag IHJ55_RS20675 Protein ID WP_010300678.1
Coordinates 4663493..4663882 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID C6DIE5
Locus tag IHJ55_RS20670 Protein ID WP_010300679.1
Coordinates 4663275..4663496 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IHJ55_RS20645 4658822..4659769 + 948 WP_203470561.1 isoaspartyl peptidase/L-asparaginase -
IHJ55_RS20650 4659974..4660882 + 909 WP_014913736.1 LysR family transcriptional regulator -
IHJ55_RS20655 4660981..4661844 + 864 WP_010300687.1 YicC family protein -
IHJ55_RS20660 4662196..4662558 - 363 WP_072037086.1 hypothetical protein -
IHJ55_RS20665 4662903..4663226 + 324 WP_203470562.1 hypothetical protein -
IHJ55_RS20670 4663275..4663496 + 222 WP_010300679.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IHJ55_RS20675 4663493..4663882 + 390 WP_010300678.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
IHJ55_RS20680 4664225..4665019 + 795 WP_203470563.1 class I SAM-dependent methyltransferase -
IHJ55_RS20685 4665298..4665855 + 558 WP_203470564.1 hypothetical protein -
IHJ55_RS20690 4665903..4666454 - 552 WP_203471318.1 hypothetical protein -
IHJ55_RS20695 4666522..4666908 + 387 WP_010300669.1 hypothetical protein -
IHJ55_RS20700 4666951..4667313 + 363 WP_161509965.1 DUF596 domain-containing protein -
IHJ55_RS20705 4667324..4668538 - 1215 WP_039508380.1 AI-2E family transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(5-120)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-53)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14583.43 Da        Isoelectric Point: 5.9739

>T177839 WP_010300678.1 NZ_CP063242:4663493-4663882 [Pectobacterium carotovorum]
MNWVSAQEVIAFHDRILQRLPGVAGMPDPGRAEAIIYRVQNRTHYEGITDVFELAATYWVAVARGHIFNDGNKRTAFFVT
MTFLYRNGVLVRDHDNTLENLTVEAATGAKNVDQLAQHLRNLEDEISPT

Download         Length: 390 bp

>T177839 NZ_CP083715:2473337-2473687 [Bacillus velezensis]
TTGATTGTAAAGCGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGCGTACGCCCGGT
TTTAGTGATCCAAAATGATATCGGAAATCGCTTTAGCCCGACTGCTATTGTTGCAGCCATAACAGCCCAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATTGATGCAAAACGCTACGGTTTTGAAAGAGATTCCGTTATTTTGCTGGAGCAAATT
CGGACGATTGACAAGCAAAGATTAACGGATAAAATAACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCCT
GCAAATCAGTTTGGCACTCATTGATTTTTAG

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8135.01 Da        Isoelectric Point: 5.0359

>AT177839 WP_010300679.1 NZ_CP063242:4663275-4663496 [Pectobacterium carotovorum]
MRTYTSTQARANISEVLDAATHGEPVEITRRDGSSAVVISKAEFEAYQNAKLDAEFDLIMQRHGHTIEALTDR

Download         Length: 222 bp

>AT177839 NZ_CP083715:2473050-2473331 [Bacillus velezensis]
TTGTCTGAATCCAGCGCAAGAACCGAAATGAAAATCAGCTTGCCCGAAAACTTAGTAGCTGAATTGGATGGTGTAGCGAT
GCGGGAGAAACGAAGCAGAAACGAACTGATATCACAAGCAGTGAGAGCGTATGTCAGCGAACGGACAACTCGCCATAACC
GTGATTTGATGAGACGCGGGTATATGGAAATGGCGAAAATCAACTTGAATATCTCTTCTGAGGCTCACTATGCTGAGTGC
GAAGCAGAAACGACCGTTGAGCGCTTAGTCAGCGGAGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7V8T7U1

Antitoxin

Source ID Structure
AlphaFold DB A0A221TFG2

References