Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 4305973..4306556 Replicon chromosome
Accession NZ_CP063242
Organism Pectobacterium carotovorum strain XP-13

Toxin (Protein)


Gene name parE Uniprot ID A0A7V8PTK4
Locus tag IHJ55_RS19035 Protein ID WP_010296214.1
Coordinates 4305973..4306278 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7V8PT23
Locus tag IHJ55_RS19040 Protein ID WP_010296210.1
Coordinates 4306266..4306556 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IHJ55_RS19020 4302332..4303291 + 960 WP_029367586.1 ABC transporter permease -
IHJ55_RS19025 4303284..4304150 + 867 WP_010285293.1 ABC transporter permease -
IHJ55_RS19030 4304147..4305853 + 1707 WP_203470483.1 ABC transporter ATP-binding protein -
IHJ55_RS19035 4305973..4306278 - 306 WP_010296214.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IHJ55_RS19040 4306266..4306556 - 291 WP_010296210.1 ribbon-helix-helix protein, CopG family Antitoxin
IHJ55_RS19045 4306618..4307520 - 903 WP_203470484.1 helix-turn-helix domain-containing protein -
IHJ55_RS19050 4307545..4308384 - 840 WP_039493893.1 HTH-type transcriptional activator RhaS -
IHJ55_RS19055 4308721..4310211 + 1491 WP_203470485.1 rhamnulokinase -
IHJ55_RS19060 4310208..4311470 + 1263 WP_010296200.1 L-rhamnose isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-96)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-46)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11576.44 Da        Isoelectric Point: 9.8325

>T177838 WP_010296214.1 NZ_CP063242:c4306278-4305973 [Pectobacterium carotovorum]
MPQVIVSERARRDLQRLQDFLKNKNALAAKKAAEVLIRGIRQLEALPNIGRPVEHLPLEYQELVIEFGSSGYVMLYRHDE
LTGRVVILTVKHQKEAGYQNP

Download         Length: 306 bp

>T177838 NZ_CP083710:101444-101731 [Enterobacter cloacae complex sp. ECL352]
ATGGCATATTTTCTGGATTTTGACGAGCGTGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGCTAAA
AAATAAGTTGGCTGAAGTGCTTGAGTCACCCCGAATTGATGCGAACAAGCTTCGGGGTATGCATGACTGTTACAAAATTA
AGCTCCGGTCTTCAGGCTATCGTCTTGTATATCAGGTCATAGACGAGAAGGTTGTCGTCTTTGTGATTTCTGTCGGGAAA
AGAGAGCGCTCGGAAGTTTATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 11064.13 Da        Isoelectric Point: 4.7692

>AT177838 WP_010296210.1 NZ_CP063242:c4306556-4306266 [Pectobacterium carotovorum]
MADTTRQTTTLRIDQDIKERLKTLADDRNSSAHALMLEAIAEYVEREEKRSQYRKEALAAWEDYQDTGKHITADETVTWL
ESWGSGHEQDAPACHK

Download         Length: 291 bp

>AT177838 NZ_CP083710:101205-101444 [Enterobacter cloacae complex sp. ECL352]
ATGGGTAGCATCAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCTGCGCTTGAAAAAATGGGTGTAACTCC
CTCTGAGGCACTTCGCCTCATGCTTGAATATATTGCTGACAATGAACGTTTGCCGTTCAAACAGACACTCCTGAGTGATG
AGGATGCTGAGCTCGTGGAGATCGTGAAAGAACGACTTCGCAATCCTAAGCCAGTACGTGTGACGCTGGATGAGCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7V8PTK4

Antitoxin

Source ID Structure
AlphaFold DB A0A7V8PT23

References