Detailed information of TA system TA177836

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 4224245..4225038
• Replicon: chromosome
• Accession: NZ_CP063242
• Organism: Pectobacterium carotovorum strain XP-13

Toxin (Protein)

• Gene name: TacT2
• Uniprot ID: -
• Locus tag: IHJ55_RS18695
• Protein ID: WP_203470457.1
• Coordinates: 4224245..4224748 (-)
• Length: 168 a.a.

Antitoxin (Protein)

• Gene name: TacA2
• Uniprot ID: -
• Locus tag: IHJ55_RS18700
• Protein ID: WP_203470458.1
• Coordinates: 4224745..4225038 (-)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IHJ55_RS18670	4219491..4219661	-	171	WP_203470453.1	hypothetical protein	-
IHJ55_RS18675	4219803..4220537	+	735	WP_203470454.1	molybdopterin-guanine dinucleotide biosynthesis protein MobC	-
IHJ55_RS18680	4220666..4220884	-	219	WP_053010239.1	KTSC domain-containing protein	-
IHJ55_RS18685	4220895..4222790	-	1896	WP_203470455.1	ATP-binding protein	-
IHJ55_RS18690	4222780..4223979	-	1200	WP_203470456.1	SIR2 family protein	-
IHJ55_RS18695	4224245..4224748	-	504	WP_203470457.1	GNAT family N-acetyltransferase	Toxin
IHJ55_RS18700	4224745..4225038	-	294	WP_203470458.1	DUF1778 domain-containing protein	Antitoxin
IHJ55_RS18705	4225526..4225735	-	210	WP_039470597.1	helix-turn-helix domain-containing protein	-
IHJ55_RS18710	4225732..4226328	-	597	WP_203470459.1	ash family protein	-
IHJ55_RS18715	4226657..4227439	+	783	WP_103161895.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	-
IHJ55_RS18720	4227426..4228355	+	930	WP_039539679.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	-
IHJ55_RS18725	4228642..4229544	-	903	WP_203470460.1	LysR family transcriptional regulator	-
IHJ55_RS18730	4229673..4229936	+	264	WP_010286385.1	DUF2798 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (44-143)

Antitoxin

• Vibrio phage ICP1, Orf50 (4-95)

Sequences

Toxin

Protein

• Length: 168 a.a.
• Molecular weight: 18040.89 Da
• Isoelectric Point: 6.8533

>T177836 WP_203470457.1 NZ_CP063242:c4224748-4224245 [Pectobacterium carotovorum]
MISAPEPLHAEHALSSFCCGVESMDNWLKLRAMKNQVTGASRTFVSCDDSKVLAYYSLASSAVATNAAPGRFRRNMPDPI
PVVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVADTIGIRGILVHALSDEAREFYLRVGFEPSPIDQMMLMVTLGDLVG
SINMNVE

Nucleotide

• Length: 504 bp

>T177836 NZ_CP083709:c3384410-3384192 [Enterobacter cloacae complex sp. ECL352]
ATGTCTGATAAACCACTCACAAAAATCGATTATTTGATGCGCTTACGACGTTGTCAGTCAATTGACACGCTTGAGCGCGT
CATTGAAAAGAATAAATACGAGCTTTCTGATAATGAACTGGCGGTATTTTATTCAGCCGCTGACCATCGTCTTGCTGAAC
TGACAATGAATAAACTGTATGACAAAATCCCTACTTCTGTGTGGAAATTTGTCCGTTAA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10955.58 Da
• Isoelectric Point: 10.1968

>AT177836 WP_203470458.1 NZ_CP063242:c4225038-4224745 [Pectobacterium carotovorum]
MPVTNNVSVKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIDQRIIMADPDAYQEFLARLDQVPSPN
AALRKTMQTPAPWEQKK

Nucleotide

• Length: 294 bp

>AT177836 NZ_CP083709:c3384812-3384438 [Enterobacter cloacae complex sp. ECL352]
ATGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAATCTTGATGAAAGTAACCATGGCTGGGTAAACGACCCAACGTCTGCCATCAATTTACAGTTGAATGAGCTGATAGAGC
ATATCGCAACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGCTCATTGAGCAAATTGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGTTACGGCATTAACGCTCAGGATTTGCAAAAATGGCGTAAATCGGGAAATCGGCT
ATTCCGCTGTTTCGTCAACGTGAGCAGAGCTAACCCGGTGAGTCTTTCCTGTTAA