Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3537577..3538202 Replicon chromosome
Accession NZ_CP063242
Organism Pectobacterium carotovorum strain XP-13

Toxin (Protein)


Gene name Hha Uniprot ID C6DB72
Locus tag IHJ55_RS15660 Protein ID WP_005976087.1
Coordinates 3537999..3538202 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID C6DB73
Locus tag IHJ55_RS15655 Protein ID WP_005976089.1
Coordinates 3537577..3537945 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IHJ55_RS15640 3533218..3536346 + 3129 WP_010303023.1 multidrug efflux RND transporter permease subunit -
IHJ55_RS15645 3536568..3536816 + 249 WP_039506474.1 type B 50S ribosomal protein L31 -
IHJ55_RS15650 3536834..3536977 + 144 WP_005976091.1 type B 50S ribosomal protein L36 -
IHJ55_RS15655 3537577..3537945 + 369 WP_005976089.1 Hha toxicity modulator TomB Antitoxin
IHJ55_RS15660 3537999..3538202 + 204 WP_005976087.1 hemolysin expression modulator Hha Toxin
IHJ55_RS15670 3538946..3539266 + 321 WP_010282239.1 MGMT family protein -
IHJ55_RS15675 3539286..3539867 - 582 WP_010303016.1 YbaY family lipoprotein -
IHJ55_RS15680 3540080..3540943 + 864 WP_010303014.1 acyl-CoA thioesterase II -
IHJ55_RS15685 3541078..3542364 - 1287 WP_039472387.1 ammonium transporter AmtB -
IHJ55_RS15690 3542404..3542742 - 339 WP_002208627.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8145.52 Da        Isoelectric Point: 8.9008

>T177833 WP_005976087.1 NZ_CP063242:3537999-3538202 [Pectobacterium carotovorum]
MKKIDYLMRLRKCTTIDTLERVIEKNKYELSNDELEMFFSAADHRLAELTMNKLYDKVPTAVWRYVR

Download         Length: 204 bp

>T177833 NZ_CP083709:c1652872-1652531 [Enterobacter cloacae complex sp. ECL352]
ATGAAAACTTTACCTGCAACAACTCAGCGGGCGGTGAAGCCCTGCCTGTCACCCGTGGCTGTCTGGCAAATGCTACTGAC
ACGCCTGCTGGAACAGCACTATGGTCTCACCCTCAACGACACACCGTTCAGTGAGGAACGTGTTATACAGGAACATATCG
ATGCCGGGATCTCGCTGGCTGATGCCGTGAATTTTCTGGTGGAAAAATACGAACTGGTGCGTATCGACAGGAAGGGATTT
AACTGGCAGGAACAATCCCCTTATCTCCGGGCTGTAGACATTCTGCGAGCGCGGCAGGCAACTGGCTTGTTGCGGCAAAG
CCGTAAAAATTCGGTACGGTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14032.77 Da        Isoelectric Point: 4.4787

>AT177833 WP_005976089.1 NZ_CP063242:3537577-3537945 [Pectobacterium carotovorum]
MDEYTPKHYDIAQLRFLCENLCDESIATLGDSSHGWVNDPTSAINLQLNELIEHIATFILTFKIKYPNESELSEQVEKYL
DDTYVLFSNYGINDAELRRWQKSKAKLFGMFSGENVCTPAKT

Download         Length: 369 bp

>AT177833 NZ_CP083709:c1653210-1652893 [Enterobacter cloacae complex sp. ECL352]
ATGACTCACATCACATGGGGCCTGCAGCGGAATATCACGCCGCGCCTGGGAGCCCGTCTGGTGCAGGAAGGGAACCGGAT
GCATTATCTGGCTGACCGGGCCAGCATCACCGGCAAGTTCAGTGACACCGAATGCCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCCGCCAGATGGAATCGATGCTGACCACTGGTGAAATGAATCCCCGCAATGCCCACTGTGTCACCCTGTTCCAC
AACGGTTTCACCTGTGAAGCCGACACCCTTGGCAGTTGCGGTTACGTGTACATCGCCATTTATCCCACCCAGCGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1D7Z3F0

Antitoxin

Source ID Structure
AlphaFold DB A0A1D7Z3G5

References