Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 199443..200060 Replicon chromosome
Accession NZ_CP063242
Organism Pectobacterium carotovorum strain XP-13

Toxin (Protein)


Gene name hicA Uniprot ID C6DHN3
Locus tag IHJ55_RS00830 Protein ID WP_010281507.1
Coordinates 199881..200060 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A7T5QP09
Locus tag IHJ55_RS00825 Protein ID WP_010299285.1
Coordinates 199443..199853 (-) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IHJ55_RS00810 195308..196351 - 1044 WP_010281514.1 DNA-binding transcriptional regulator CytR -
IHJ55_RS00815 196661..198859 - 2199 WP_161508663.1 primosomal protein N' -
IHJ55_RS00820 199131..199346 + 216 WP_010281510.1 50S ribosomal protein L31 -
IHJ55_RS00825 199443..199853 - 411 WP_010299285.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
IHJ55_RS00830 199881..200060 - 180 WP_010281507.1 type II toxin-antitoxin system HicA family toxin Toxin
IHJ55_RS00835 200160..201170 - 1011 WP_203470640.1 iron ABC transporter permease -
IHJ55_RS00840 201167..202129 - 963 WP_103971393.1 ABC transporter substrate-binding protein -
IHJ55_RS00845 202139..202936 - 798 WP_203470641.1 ABC transporter ATP-binding protein -
IHJ55_RS00850 203153..203470 - 318 WP_005973355.1 met regulon transcriptional regulator MetJ -
IHJ55_RS00855 203658..204818 + 1161 WP_010299271.1 cystathionine gamma-synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6560.69 Da        Isoelectric Point: 10.7838

>T177828 WP_010281507.1 NZ_CP063242:c200060-199881 [Pectobacterium carotovorum]
MDSRTLIAEIKADGWELIRVNGSHHHFMHPSKPGLVTIPHPKKDLPIGTVKSIRKQAGI

Download         Length: 180 bp

>T177828 NZ_CP083707:24210-24362 [Escherichia coli]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCATCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGGACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14549.41 Da        Isoelectric Point: 4.3391

>AT177828 WP_010299285.1 NZ_CP063242:c199853-199443 [Pectobacterium carotovorum]
MFYPIAIEAGDDTHAYGVTVPDLPGCFSAGDTLDDAIANAKEAITGHIELLIEMGQDIPTVSSVGQLAKNSEYAGYTWAV
VDIDVTRLMGGSEKINVTLPKSLIDRIDRCVASNPEFKSRSGFLAQAALERISSSR

Download         Length: 411 bp

>AT177828 NZ_CP083707:c24160-24098 [Escherichia coli]
TCGAAGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7W2I1S0

Antitoxin

Source ID Structure
AlphaFold DB A0A7T5QP09

References