Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 4563542..4564077 Replicon chromosome
Accession NZ_CP063241
Organism Pectobacterium brasiliense strain ZLMLSHJ5

Toxin (Protein)


Gene name relE Uniprot ID C6DJA0
Locus tag IHJ54_RS20245 Protein ID WP_015842269.1
Coordinates 4563790..4564077 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q6DB37
Locus tag IHJ54_RS20240 Protein ID WP_010281712.1
Coordinates 4563542..4563793 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IHJ54_RS20210 4558981..4559307 + 327 WP_014913674.1 helix-turn-helix domain-containing protein -
IHJ54_RS20215 4559292..4559606 + 315 WP_039528006.1 HipA N-terminal domain-containing protein -
IHJ54_RS20220 4559603..4560643 + 1041 WP_203449716.1 HipA domain-containing protein -
IHJ54_RS20225 4560703..4561326 - 624 WP_203449717.1 LysE family translocator -
IHJ54_RS20230 4561594..4562349 + 756 WP_203449718.1 thiol:disulfide interchange protein DsbG -
IHJ54_RS20235 4562383..4563288 - 906 WP_203449719.1 siderophore-interacting protein -
IHJ54_RS20240 4563542..4563793 + 252 WP_010281712.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IHJ54_RS20245 4563790..4564077 + 288 WP_015842269.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IHJ54_RS20250 4564197..4565549 - 1353 WP_014913667.1 glutathione-disulfide reductase -
IHJ54_RS20255 4565677..4566519 - 843 WP_039527996.1 23S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ -
IHJ54_RS20260 4566738..4567466 + 729 WP_039498362.1 DUF1266 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11074.15 Da        Isoelectric Point: 10.3527

>T177826 WP_015842269.1 NZ_CP063241:4563790-4564077 [Pectobacterium brasiliense]
MSYSVKFREDALKEWLKLDKTIQQQFAKKLKKCCENPHIPSAKLRGMKDCYKIKLRASGFRLVYEVIDDVLIIAVVAVGK
RERSGVYHLASERMR

Download         Length: 288 bp

>T177826 NZ_CP083704:37001-37153 [Escherichia coli]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCGTCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGGACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9117.47 Da        Isoelectric Point: 4.0637

>AT177826 WP_010281712.1 NZ_CP063241:4563542-4563793 [Pectobacterium brasiliense]
MPNIILSDTSASVSELKKNPMATVNAGDGLPVAILNRNQPAFYCIPADLYEKMLDALDDQELVKLIGERKNQPLVDVDLD
SFL

Download         Length: 252 bp

>AT177826 NZ_CP083704:c36949-36889 [Escherichia coli]
GAGGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S0XQ75

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2EZP0

References