Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1265780..1266405 Replicon chromosome
Accession NZ_CP063241
Organism Pectobacterium brasiliense strain ZLMLSHJ5

Toxin (Protein)


Gene name Hha Uniprot ID C6DB72
Locus tag IHJ54_RS05455 Protein ID WP_005976087.1
Coordinates 1265780..1265983 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID Q6D809
Locus tag IHJ54_RS05460 Protein ID WP_010282247.1
Coordinates 1266037..1266405 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IHJ54_RS05425 1261112..1261450 + 339 WP_002208627.1 P-II family nitrogen regulator -
IHJ54_RS05430 1261490..1262776 + 1287 WP_014914537.1 ammonium transporter AmtB -
IHJ54_RS05435 1262916..1263779 - 864 WP_014914538.1 acyl-CoA thioesterase II -
IHJ54_RS05440 1263992..1264573 + 582 WP_203450148.1 YbaY family lipoprotein -
IHJ54_RS05445 1264593..1264913 - 321 WP_010282239.1 MGMT family protein -
IHJ54_RS05455 1265780..1265983 - 204 WP_005976087.1 hemolysin expression modulator Hha Toxin
IHJ54_RS05460 1266037..1266405 - 369 WP_010282247.1 Hha toxicity modulator TomB Antitoxin
IHJ54_RS05465 1267004..1267147 - 144 WP_005976091.1 type B 50S ribosomal protein L36 -
IHJ54_RS05470 1267165..1267413 - 249 WP_039274617.1 type B 50S ribosomal protein L31 -
IHJ54_RS05475 1267644..1270772 - 3129 WP_039466835.1 multidrug efflux RND transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8145.52 Da        Isoelectric Point: 8.9008

>T177822 WP_005976087.1 NZ_CP063241:c1265983-1265780 [Pectobacterium brasiliense]
MKKIDYLMRLRKCTTIDTLERVIEKNKYELSNDELEMFFSAADHRLAELTMNKLYDKVPTAVWRYVR

Download         Length: 204 bp

>T177822 NZ_CP083702:c29347-29198 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGGTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14046.80 Da        Isoelectric Point: 4.4787

>AT177822 WP_010282247.1 NZ_CP063241:c1266405-1266037 [Pectobacterium brasiliense]
MDEYTPKHYDIAQLRFLCENLCDESIATLGDSSHGWVNDPTSAINLQLNELIEHIATFILTFKIKYPNESELSEQVEKYL
DDTYVLFSNYGINDAELRRWQKSKAKLFGMFSGENICTPAKT

Download         Length: 369 bp

>AT177822 NZ_CP083702:29391-29452 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1D7Z3F0

Antitoxin

Source ID Structure
AlphaFold DB A0A086EI31

References