Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 151074..151708 Replicon chromosome
Accession NZ_CP063241
Organism Pectobacterium brasiliense strain ZLMLSHJ5

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag IHJ54_RS00640 Protein ID WP_080162911.1
Coordinates 151074..151349 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A433N1R7
Locus tag IHJ54_RS00645 Protein ID WP_014917022.1
Coordinates 151346..151708 (+) Length 121 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IHJ54_RS00625 148094..149464 - 1371 WP_010281575.1 envelope stress sensor histidine kinase CpxA -
IHJ54_RS00630 149461..150159 - 699 WP_010281574.1 envelope stress response regulator transcription factor CpxR -
IHJ54_RS00635 150313..150837 + 525 WP_203449802.1 cell-envelope stress modulator CpxP -
IHJ54_RS00640 151074..151349 + 276 WP_080162911.1 type II toxin-antitoxin system HicA family toxin Toxin
IHJ54_RS00645 151346..151708 + 363 WP_014917022.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
IHJ54_RS00650 152082..153269 + 1188 WP_039511454.1 sugar transporter -
IHJ54_RS00655 153342..154244 + 903 WP_180789217.1 CDF family cation-efflux transporter FieF -
IHJ54_RS00660 154451..155413 + 963 WP_010306854.1 6-phosphofructokinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-85)

Antitoxin

Uncharacterised protein family HicB

(61-113)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10024.61 Da        Isoelectric Point: 11.1875

>T177815 WP_080162911.1 NZ_CP063241:151074-151349 [Pectobacterium brasiliense]
MQGKIASLRKKQRETLSQIFKTPVLSGVKWSNIESLVTALGGEIKEGSGSRVRFLLNGSIARFHRPHPSPDTDKGALVSL
REWLESIGVKP

Download         Length: 276 bp

>T177815 NZ_CP083701:3842816-3842923 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 121 a.a.        Molecular weight: 13504.31 Da        Isoelectric Point: 4.4969

>AT177815 WP_014917022.1 NZ_CP063241:151346-151708 [Pectobacterium brasiliense]
MTKALNTPNTMVVSGQPAIISYVPEMGMFRGKFIGLSGYCDFVADSINGLRSEGEISLREYLEDCQENGIEPYEREEKVK
TFTLRYPESFGERLTIAAAERQISVNTFIVETLSEHLKQA

Download         Length: 363 bp

>AT177815 NZ_CP083701:c3842767-3842704 [Escherichia coli]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A433N1R7

References