Detailed information of TA system TA177812

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 4350245..4350914
• Replicon: chromosome
• Accession: NZ_CP063238
• Organism: Serratia marcescens strain SCH909

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: A0A2V4FX75
• Locus tag: SCH909_RS20800
• Protein ID: WP_033649453.1
• Coordinates: 4350245..4350667 (-)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A8G2G4M4
• Locus tag: SCH909_RS20805
• Protein ID: WP_004931679.1
• Coordinates: 4350648..4350914 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SCH909_RS20780	4346135..4346653	+	519	WP_060422130.1	flavodoxin FldB	-
SCH909_RS20785	4346690..4348054	-	1365	WP_060422128.1	cell envelope integrity protein CreD	-
SCH909_RS20790	4348135..4349553	-	1419	WP_033654070.1	two-component system sensor histidine kinase CreC	-
SCH909_RS20795	4349550..4350245	-	696	WP_049232287.1	two-component system response regulator CreB	-
SCH909_RS20800	4350245..4350667	-	423	WP_033649453.1	protein YgfX	Toxin
SCH909_RS20805	4350648..4350914	-	267	WP_004931679.1	FAD assembly factor SdhE	Antitoxin
SCH909_RS20810	4351235..4352227	+	993	WP_060422126.1	tRNA-modifying protein YgfZ	-
SCH909_RS20815	4352266..4352763	-	498	WP_033649451.1	DUF2165 domain-containing protein	-
SCH909_RS20820	4352914..4353588	-	675	WP_033654067.1	hemolysin III family protein	-
SCH909_RS20825	4353772..4354380	+	609	WP_025304127.1	HD domain-containing protein	-
SCH909_RS20830	4354407..4355333	-	927	WP_033635835.1	ribokinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 16471.59 Da
• Isoelectric Point: 10.8114

>T177812 WP_033649453.1 NZ_CP063238:c4350667-4350245 [Serratia marcescens]
VAQWRCDIRISWRTQLFSLLTHGVLILLILISPWPEGFGPLWLVLLTLVVFQCIRSQKRIAAAQGELRLLADRRFSWHGR
EWRLAKKPWMPGYGMLLTLLPMEGKKRRRLWLASDCMSKEEWRHLRQLLLYPPAGDGEDP

Nucleotide

• Length: 423 bp

>T177812 NZ_CP083701:2645997-2646275 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTATTTGGGTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10387.89 Da
• Isoelectric Point: 4.7921

>AT177812 WP_004931679.1 NZ_CP063238:c4350914-4350648 [Serratia marcescens]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLNDADKALFIRLLECDDPDLFNWLMNHGAPQDGELQRMVTLIQTRN
KDRGPVAM

Nucleotide

• Length: 267 bp

>AT177812 NZ_CP083701:2645734-2645994 [Escherichia coli]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAAGTCGCGCGTGAAAAGGCATTACCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATTAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Structures

Toxin

• AlphaFold DB: A0A2V4FX75