Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 1867217..1867742 Replicon chromosome
Accession NZ_CP063238
Organism Serratia marcescens strain SCH909

Toxin (Protein)


Gene name relE Uniprot ID A0A2S4XEJ2
Locus tag SCH909_RS08965 Protein ID WP_033654647.1
Coordinates 1867217..1867501 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A8B4GIN1
Locus tag SCH909_RS08970 Protein ID WP_004928423.1
Coordinates 1867491..1867742 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SCH909_RS08940 1862477..1863610 + 1134 WP_033637812.1 putrescine ABC transporter ATP-binding subunit PotG -
SCH909_RS08945 1863635..1864597 + 963 WP_033646669.1 putrescine ABC transporter permease PotH -
SCH909_RS08950 1864594..1865439 + 846 WP_016928360.1 putrescine ABC transporter permease PotI -
SCH909_RS08955 1865544..1866023 + 480 WP_048321404.1 YbjO family protein -
SCH909_RS08960 1866093..1867220 + 1128 WP_060419788.1 23S rRNA (uracil(747)-C(5))-methyltransferase RlmC -
SCH909_RS08965 1867217..1867501 - 285 WP_033654647.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SCH909_RS08970 1867491..1867742 - 252 WP_004928423.1 prevent-host-death protein Antitoxin
SCH909_RS08975 1867844..1868578 - 735 WP_033637816.1 arginine ABC transporter substrate-binding protein -
SCH909_RS08980 1868778..1869446 - 669 WP_033637817.1 arginine ABC transporter permease ArtM -
SCH909_RS08985 1869446..1870162 - 717 WP_033637818.1 arginine ABC transporter permease ArtQ -
SCH909_RS08990 1870172..1870903 - 732 WP_033637819.1 arginine ABC transporter substrate-binding protein -
SCH909_RS08995 1870936..1871664 - 729 WP_038884338.1 arginine ABC transporter ATP-binding protein ArtP -
SCH909_RS09000 1871929..1872471 - 543 WP_033637821.1 lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10817.97 Da        Isoelectric Point: 10.6941

>T177800 WP_033654647.1 NZ_CP063238:c1867501-1867217 [Serratia marcescens]
MTYKLEFEEHALKEFKKLSPVIREQFKKKLVSVLVNPHVPANKLAGLPDCYKIKLRASGFRLVYRVMETEIVVLVLSVGK
RERSAAYTAAKKRL

Download         Length: 285 bp

>T177800 NZ_CP083693:c1102003-1101689 [Bartonella taylorii]
ATGATACATAAAAGAGTGAATGAAGGTGATTTGGTGATTGAATCTTTTGCGGATAAGCGTTGTAAAGATCTTTTAGAAGG
TAATTCGCCTAAAGGTTTTCCAACAACTCTAGTACGTATAGCCCAAAGAAAATTGTTTATGCTCGATAAAGCGGTTGACC
TTAAGGATTTACGCAGTCCTCCAGGAAATCATTTAGAAGCATTGAAAGGAGAGCGTAAAGGTCAATATTCTATTCGTATT
AATGACCAGTTTCGTATTTGTTTTGAATGGCGCTCTAATGGCGCCTATGAAGTTGAAATCGTAGATTATCATTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9108.39 Da        Isoelectric Point: 4.5203

>AT177800 WP_004928423.1 NZ_CP063238:c1867742-1867491 [Serratia marcescens]
MTVQPILADSAVSISDFKKSPNAALKEAQGQPVAVLTNGKISGYYVSPETWEAIAEYLEDIELAEIVRSRMNGKRIKVNL
DDL

Download         Length: 252 bp

>AT177800 NZ_CP083693:c1101672-1101376 [Bartonella taylorii]
ATGAAAAATTATATTGCTATTCATCCCGGAGAAATTTTAAGAGAGGAATATTTAAAAGAATATGCTCTCTCTGCTTATGC
CCTTGCAAAAGCATTAAATGTTCCACGCACGAGAATAGAACGTATTGTTGCTGAAAATAGTCCAGTGACTCCCGATACTG
CTCTCAGATTAGCCTATTTTTTTGATACTACTGCTGAATTTTGGCTCAACATGCAAGCTGCTTATGACGTTAGTATATTA
CAAACTGAAAAAGCAGACGAATTTGCCAAAATCAATAAATTTGAATGTAGGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S4XEJ2

Antitoxin

Source ID Structure
AlphaFold DB A0A8B4GIN1

References