Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 1230618..1231171 Replicon chromosome
Accession NZ_CP063238
Organism Serratia marcescens strain SCH909

Toxin (Protein)


Gene name ccdB Uniprot ID A0A2V4FZ31
Locus tag SCH909_RS05740 Protein ID WP_019454426.1
Coordinates 1230618..1230932 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A2V4GJ62
Locus tag SCH909_RS05745 Protein ID WP_029988820.1
Coordinates 1230935..1231171 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SCH909_RS05720 1226383..1227540 - 1158 WP_033654978.1 YbfB/YjiJ family MFS transporter -
SCH909_RS05725 1227646..1228566 + 921 WP_033654969.1 LysR family transcriptional regulator -
SCH909_RS05730 1228597..1229721 + 1125 WP_033637718.1 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase -
SCH909_RS05735 1229736..1230578 + 843 WP_015377214.1 S-formylglutathione hydrolase -
SCH909_RS05740 1230618..1230932 - 315 WP_019454426.1 CcdB family protein Toxin
SCH909_RS05745 1230935..1231171 - 237 WP_029988820.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
SCH909_RS05750 1231278..1232186 - 909 WP_171887866.1 glutathione ABC transporter permease GsiD -
SCH909_RS05755 1232196..1233116 - 921 WP_038880960.1 glutathione ABC transporter permease GsiC -
SCH909_RS05760 1233169..1234704 - 1536 WP_033654972.1 glutathione ABC transporter substrate-binding protein GsiB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(9-78)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11745.68 Da        Isoelectric Point: 5.0488

>T177799 WP_019454426.1 NZ_CP063238:c1230932-1230618 [Serratia marcescens]
MQFTVYANRGNSAVYPLLLDVTSDIIGQLNRRVVIPLLPVEKYPGSTRPERLIPLIRLIDDNEYAVMTYEMASIPVRALG
AEFCDVSQYRTRIKAAIDFLLDGI

Download         Length: 315 bp

>T177799 NZ_CP083693:c1100715-1100434 [Bartonella taylorii]
ATGCGGACGATTGAACGTACCAGTATCTTCAAACGTGATTTCAAGCGTGAAATGAAAGGACGGTATAGGCATCTTTTAGA
TACTGATTTGCGCCAAATCATTGCAGCATTAGCAAATGACCAGCCTTTAGAAGCTCGATATCATGACCATGCATTGACTG
GGAATTGGAGCAATTATCGAGATTGCCATATTCGACCTGACTTAGTATTGATTTATCGCTTGATTGGTCAAGATCGATTG
ATTTTAGTGCGCCTGGGCTCCCATTCAAAACTTGATCTTTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9082.13 Da        Isoelectric Point: 5.7070

>AT177799 WP_029988820.1 NZ_CP063238:c1231171-1230935 [Serratia marcescens]
MPVKQRTTQSVTMTLERSLLSRAREAGINLSATLTAALDAELRQHERIKWQEENREALEALNRFNDEHGCFSDEYRTF

Download         Length: 237 bp

>AT177799 NZ_CP083693:c1100965-1100702 [Bartonella taylorii]
ATGGCTGCTAGTCGTATGGTTCAGGCGCGTGTACCAGAAGAAATTCAAAATATCGCTAATCAAGTTATTCAAGCTTCAGG
TTTATCAGTAAGTGATGTTGTGAGAGTGTTGATGACGCGTATTGCACAAGATAAAGCTATTCCGTCCTTCTTGTTTCAAC
CTAATGCGGAAACTATAGCGGCTTTTGCAGAACTAGAGGAAGGTAACTTAAAAAAGTTTCATTCCGTAGACGAATTATTT
GATGATCTCTATGCGGACGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2V4FZ31

Antitoxin

Source ID Structure
AlphaFold DB A0A2V4GJ62

References