Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1116364..1116985 Replicon chromosome
Accession NZ_CP063238
Organism Serratia marcescens strain SCH909

Toxin (Protein)


Gene name Hha Uniprot ID A0A8B4G7F9
Locus tag SCH909_RS05135 Protein ID WP_004940313.1
Coordinates 1116364..1116567 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A2X2G5J9
Locus tag SCH909_RS05140 Protein ID WP_004940312.1
Coordinates 1116617..1116985 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SCH909_RS05110 1112155..1112601 + 447 WP_039566985.1 type II secretion system protein M -
SCH909_RS05115 1112638..1113453 + 816 WP_060420359.1 A24 family peptidase -
SCH909_RS05120 1113450..1113812 - 363 WP_060420357.1 type II secretion system pilot lipoprotein GspS -
SCH909_RS05125 1114066..1115496 + 1431 WP_043146738.1 N-acetylglucosamine-binding protein GbpA -
SCH909_RS05130 1115549..1116067 + 519 WP_060420355.1 cytochrome b/b6 domain-containing protein -
SCH909_RS05135 1116364..1116567 - 204 WP_004940313.1 hemolysin expression modulator Hha Toxin
SCH909_RS05140 1116617..1116985 - 369 WP_004940312.1 Hha toxicity modulator TomB Antitoxin
SCH909_RS05145 1117144..1117497 - 354 WP_033653245.1 hypothetical protein -
SCH909_RS05150 1117904..1118617 + 714 WP_033647273.1 ABC transporter ATP-binding protein -
SCH909_RS05155 1118614..1119471 + 858 WP_033637343.1 metal ABC transporter permease -
SCH909_RS05160 1119497..1120375 + 879 WP_041033680.1 metal ABC transporter substrate-binding protein -
SCH909_RS05165 1120482..1120622 - 141 WP_004940304.1 type B 50S ribosomal protein L36 -
SCH909_RS05170 1120635..1120889 - 255 WP_004940303.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8107.37 Da        Isoelectric Point: 6.9756

>T177798 WP_004940313.1 NZ_CP063238:c1116567-1116364 [Serratia marcescens]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPTSVWKYVR

Download         Length: 204 bp

>T177798 NZ_CP083693:1097739-1097939 [Bartonella taylorii]
ATGGAACAAGATAGCCGAAAAATCATTGCAAAATTAAAGCGTGATGGCTTTGAACTTGTCAAAGTAAAAGGTTCTCATCA
TAAATTAAAAAAAGATGGTAAGGTTGTTATTGTTCCACACCCTAAAAAAAATCTTCCGATTGGGACAGCACGTTCTATCG
CACAACAAGCAGGCTGGTTAAAAAAAGGAGAAGAAGAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14261.95 Da        Isoelectric Point: 4.4314

>AT177798 WP_004940312.1 NZ_CP063238:c1116985-1116617 [Serratia marcescens]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSSVNLQLNELIEHIASFVMSYKIKYMDESDLSELVEEYL
DDTYTLFSSYGINDSDLRRWQKTKARLFRMFSGEDICTTMKT

Download         Length: 369 bp

>AT177798 NZ_CP083693:1097936-1098331 [Bartonella taylorii]
ATGAAAAGATTTTTTGCTCTTGTTCATAAAGATGAATATTCTGCTTTTGGTGTTCAGTTTCCTGATTTTGAGGGGCTTTT
TTCTGCTGCTGATGAGGAAGAAAATTTAATCGCAAATGCAACAGAAGCACTTCAACTTTATTGTGAAGATATAGATATAG
TGCCTATTCCTTCAAAATTTGAAGAAGTCATACAACGGGAATCTGTCAAAACAGCTTTGTCAGAAGGAGCTTTTTTAATA
CAAGTCCCCTTTATTGAAAATGATGCAGAAGTGGTACGTACGAATATATCCATTGAAAGAGGGCTCTTACGTGCAATTGA
TGATTGTGCACAAGAAAGAGGCTTAACGAGATCTGCTTTTTTGGCAACAGCAGCGCGTCATGAGCTTAATATTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B4G7F9

Antitoxin

Source ID Structure
AlphaFold DB A0A2X2G5J9

References