Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 15178..15779 Replicon chromosome
Accession NZ_CP063238
Organism Serratia marcescens strain SCH909

Toxin (Protein)


Gene name vapC Uniprot ID A0A2V4FS51
Locus tag SCH909_RS00070 Protein ID WP_033649548.1
Coordinates 15178..15558 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A2S4X5L5
Locus tag SCH909_RS00075 Protein ID WP_039568270.1
Coordinates 15558..15779 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SCH909_RS00045 10431..11711 + 1281 WP_060423504.1 DUF3748 domain-containing protein -
SCH909_RS00050 11742..12089 - 348 WP_033636538.1 YceK/YidQ family lipoprotein -
SCH909_RS00055 12400..12813 + 414 WP_047569943.1 heat shock chaperone IbpA -
SCH909_RS00060 12914..13342 + 429 WP_004933922.1 heat shock chaperone IbpB -
SCH909_RS00065 13509..15167 + 1659 WP_033649549.1 putative transporter -
SCH909_RS00070 15178..15558 - 381 WP_033649548.1 type II toxin-antitoxin system VapC family toxin Toxin
SCH909_RS00075 15558..15779 - 222 WP_039568270.1 ribbon-helix-helix protein, CopG family Antitoxin
SCH909_RS00080 15855..17105 - 1251 WP_033645138.1 valine--pyruvate transaminase -
SCH909_RS00085 17241..19304 - 2064 WP_060423501.1 alpha-amylase -
SCH909_RS00090 19501..19653 + 153 WP_019455508.1 hypothetical protein -
SCH909_RS00095 19655..20632 - 978 WP_016929588.1 glyoxylate/hydroxypyruvate reductase GhrB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-102)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-40)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14171.50 Da        Isoelectric Point: 7.3170

>T177795 WP_033649548.1 NZ_CP063238:c15558-15178 [Serratia marcescens]
MVAQRALFDTNILIDYLNGIPQAKDVLTEYHINPAISAITWMEVMVGAKKQGPALELKTRQFLGQFLLLPITDEVAERAV
ELRHSQHVKLPDAIVWATAQVGFRTLISRNPKDFGTDNGVLMPYRL

Download         Length: 381 bp

>T177795 NZ_CP083690:4117293-4117649 [Serratia sp. HRI]
ATGATCTTTTTGACCGCAGAGGATATTGCGGAATTCAATGCTGAAATAGTGCCTCACGGCCGCCAGGAAGGCAGAAAAGT
TGAGGCTGCCGCCAACCGCGTGCTCAATGCTTACCACTACGAAAACGTCACCGACGTTTATCGTTTGGCCGCGCTCTATC
TCATCGCCATCAGCCACGGTCACATTTTTCTTGATGGCAACAAACGTACGGCCTTCCAAAGCATGGCGCTATTTCTCGGT
ATTAATGGCATTGCACTGCGGGAAGATGCAGAATTGGTCGAAATTACGGTTGAAGCAGCTCAAGGCCGCCTCAACGTTGA
ACAAGCCGCGGAGCAACTGCGCCTGCTAACCGAATAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8607.55 Da        Isoelectric Point: 4.4791

>AT177795 WP_039568270.1 NZ_CP063238:c15779-15558 [Serratia marcescens]
MTRIVIDLPEEDLRQLDNLKNIRHIPRAEIIRQAVSRYLTENHVEDPSNAFGLWSGAMGDGVDYENRQREEWE

Download         Length: 222 bp

>AT177795 NZ_CP083690:4117087-4117296 [Serratia sp. HRI]
ATGACTACGATTAGCTACACGGCGGCGAGAAACAATTTGGCCGAGGTGCTTTTGGAAGCGCAAAAACAGCCGGTGGAAGT
GACGCGCCGCGGACACGATGAGGTTTACATCATCAGTAAGGCCGACTATGAGGTCTTGGTCAAAGCCAAGGTGAAAGCGC
GCATTCAGGCTAAACACGCGGATACGATTAAGGCGCTGGCGAATAGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2V4FS51

Antitoxin

Source ID Structure
AlphaFold DB A0A2S4X5L5

References