Detailed information of TA system TA177793

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/RHH-MazF
• Location: 95649..96173
• Replicon: plasmid pLP4
• Accession: NZ_CP063236
• Organism: Rhodococcus qingshengii strain 7B

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: IM699_RS29880
• Protein ID: WP_151097002.1
• Coordinates: 95649..95951 (-)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: IM699_RS29885
• Protein ID: WP_151097004.1
• Coordinates: 95952..96173 (-)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IM699_RS29870	92850..93647	-	798	WP_151097000.1	hypothetical protein	-
IM699_RS29875	93647..95044	-	1398	WP_151097358.1	hypothetical protein	-
IM699_RS29880	95649..95951	-	303	WP_151097002.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
IM699_RS29885	95952..96173	-	222	WP_151097004.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
IM699_RS29890	96316..96506	-	191	Protein_98	hypothetical protein	-
IM699_RS29895	96700..97998	-	1299	WP_151097008.1	AAA family ATPase	-
IM699_RS29900	98068..99255	-	1188	WP_151097010.1	hypothetical protein	-
IM699_RS29905	99252..99482	-	231	WP_042445372.1	hypothetical protein	-
IM699_RS29910	99443..100676	-	1234	Protein_102	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..416450	416450

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (8-93)

Antitoxin

• Antitoxin ParD (1-62)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 10399.87 Da
• Isoelectric Point: 4.7317

>T177793 WP_151097002.1 NZ_CP063236:c95951-95649 [Rhodococcus qingshengii]
VRPIHDAQLGGLCPVLVLTRELVRPHLGTVTVAPIRSEGRGLSTELSLGEGNGVEDGSVADCDGVTTIPVSALGANRGFL
LPAQEVLLTRALRSAFDLES

Nucleotide

• Length: 303 bp

>T177793 NZ_CP083690:c3702953-3702609 [Serratia sp. HRI]
ATGTGGCAAGTGGTGACCGTCGAACGGTTCGACGACTGGTTTTTAGCGCTGAACAACGCCCAGCAAACAAGCATCCTGGC
GGCGATCTTCAAATTACAGACGTTCGGCCCGCAATTGGCACGGCCGCATGCCGATACGCTGCATTTTTCCGACGCGGTCC
GGCAGTTGAAGGAGCTGCGCATTCAACATCGCGGGCGCCCTTTCAGGGTATTTTTCGCCTTTGACCCACAGCGGCAAGCG
GTATTGCTGTGCGGCGGCGATAAAACCGGCGACCAACGCTTTTACCAGCGCATGTTGCCCATCGCCGCCATGGAGTTTTC
ACATTATCTGGCAACCCGGAGGTAG

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 7889.95 Da
• Isoelectric Point: 7.0125

>AT177793 WP_151097004.1 NZ_CP063236:c96173-95952 [Rhodococcus qingshengii]
MSTQIAVRLPEDIVAFLDSEVSGGRAKSRAQVVLRALEREQRRQLAVRDVEILSDGAGMDSDVNIAAAHGKKS

Nucleotide

• Length: 222 bp

>AT177793 NZ_CP083690:c3702603-3702301 [Serratia sp. HRI]
ATGGCCAAACCTTTATCCCAACTGATCGACAAGCTCGATCCCGCCGTCGTTGCCACTGCCAGGCAAAAAGCGGACAAGGA
AATTTTCGAGCTGCGGCTGGCGATGCTGAGGGAAGAGCTGGCGGTCTCTCAGGTTGAATTGGCGAAGCGGCTCGGCATCA
GCCAACCCTCCGTCGCCAATTTGGAAAAGCGCGGCAGCGAAATCAAACTGTCATCGCTCAAACGCTATATCGAGGCGATG
GGTGGCACGCTGTCGCTGGATGTGCAATTGCCCAATGGCCAGCACCGCCGCATGACGCTGTAA