Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA(toxin)
Location 4372722..4373329 Replicon chromosome
Accession NZ_CP063233
Organism Pseudomonas fluorescens strain KF1

Toxin (Protein)


Gene name hicA Uniprot ID A0A855JTJ8
Locus tag IM720_RS19460 Protein ID WP_024076056.1
Coordinates 4372722..4372973 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A855JUN5
Locus tag IM720_RS19465 Protein ID WP_024076057.1
Coordinates 4372970..4373329 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IM720_RS19460 4372722..4372973 + 252 WP_024076056.1 type II toxin-antitoxin system HicA family toxin Toxin
IM720_RS19465 4372970..4373329 + 360 WP_024076057.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
IM720_RS19470 4373330..4374502 - 1173 WP_193689490.1 MFS transporter -
IM720_RS19475 4374543..4375898 - 1356 WP_069076464.1 MATE family efflux transporter -
IM720_RS19480 4375925..4376497 - 573 WP_102625608.1 DUF2239 family protein -
IM720_RS19485 4376899..4377246 - 348 WP_024076061.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-76)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9562.13 Da        Isoelectric Point: 10.0941

>T177791 WP_024076056.1 NZ_CP063233:4372722-4372973 [Pseudomonas fluorescens]
VSKNEKLLAKLLNEHMTFTWPELVTLLRRLGYTQIEGAGSRVKFDIGDPTAMITLHKPHPGNELKHYIRRQVIEQLRSGD
LIQ

Download         Length: 252 bp

>T177791 NZ_CP083690:2652760-2653140 [Serratia sp. HRI]
ATGGTGGCTCAACGGGCGTTATTCGACACCAATATCCTGATCGATTATCTCAACGGCATTCCTCAAGCCAAAGACGTTCT
GACCGAATACCACATCAACCCGGCTATTAGCGCCATCACCTGGATGGAAGTGATGGTGGGTGCCAAAAAACAGGGGCCGA
CGCTGGAGCTGAAAACGCGCCAGTTTTTAGGGCAATTCCTGCTGCTGCCTATTACCGATGAAGTTGCCGAACGCGCCGTA
GAATTGCGCCACTCACAGCATGTGAAGCTGCCGGACGCCATTATCTGGGCCACCGCGCAGGTGGGGTTCCGGACGCTCAT
CTCCCGCAACCCCAAAGATTTTGGCACTGACAACGGCGTGTTAATGCCTTACCGGCTGTAG

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 12947.70 Da        Isoelectric Point: 6.4717

>AT177791 WP_024076057.1 NZ_CP063233:4372970-4373329 [Pseudomonas fluorescens]
VNNQLKYNGYIGSIEASLEDNCLFGKILFIKALVSYEGKTVAELDAAFREAVDDYLATCQTLGQTPEKPCKGSFNVRVGH
DLHLAAALAATRKKVTLNDLTRQALNEFLQHHGADPAIG

Download         Length: 360 bp

>AT177791 NZ_CP083690:2652539-2652760 [Serratia sp. HRI]
ATGACTCGCATCGTGATCGATTTACCTGAAGAAGACCTGCGGCAGCTCGACAATCTGAAAAATATCCGCCACGTTCCCCG
GGCCGAAATCATCCGTCAGGCCGTCTCCCGTTATCTGGCGGAGAACCACGTTGAAGATCCCAGCAATGCCTTCGGGCTCT
GGTCCGGGGCGATGGGCGATGGCGTAGACTACGAAAATCGTCAGCGCGAGGAGTGGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A855JTJ8

Antitoxin

Source ID Structure
AlphaFold DB A0A855JUN5

References