Detailed information of TA system TA177790

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/upstrm_HI1419-dnstrm_HI1420
• Location: 987818..988411
• Replicon: chromosome
• Accession: NZ_CP063233
• Organism: Pseudomonas fluorescens strain KF1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: IM720_RS04275
• Protein ID: WP_102625774.1
• Coordinates: 988109..988411 (-)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A855JY32
• Locus tag: IM720_RS04270
• Protein ID: WP_024073150.1
• Coordinates: 987818..988105 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IM720_RS04250	984221..986290	-	2070	WP_024073146.1	TonB-dependent copper receptor	-
IM720_RS04255	986383..986784	-	402	WP_024073147.1	DUF2946 domain-containing protein	-
IM720_RS04260	986795..987277	-	483	WP_168232253.1	copper chaperone PCu(A)C	-
IM720_RS04265	987325..987720	-	396	WP_193690135.1	DUF2946 domain-containing protein	-
IM720_RS04270	987818..988105	-	288	WP_024073150.1	putative addiction module antidote protein	Antitoxin
IM720_RS04275	988109..988411	-	303	WP_102625774.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
IM720_RS04280	988929..989183	+	255	WP_024073152.1	hypothetical protein	-
IM720_RS04285	989227..989550	-	324	WP_024073153.1	transcriptional regulator	-
IM720_RS04290	989556..989888	-	333	Protein_846	type II toxin-antitoxin system RelE/ParE family toxin	-
IM720_RS04295	989945..990670	-	726	WP_024073155.1	cobalt-precorrin-6A reductase	-
IM720_RS04300	990667..991872	-	1206	WP_024073156.1	bifunctional cobalt-precorrin-7 (C(5))-methyltransferase/cobalt-precorrin-6B (C(15))-methyltransferase	-
IM720_RS04305	991995..993257	+	1263	WP_193690673.1	precorrin-3B synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-91)

Antitoxin

• Uncharacterized protein HI1420 (4-93)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11775.50 Da
• Isoelectric Point: 10.0002

>T177790 WP_102625774.1 NZ_CP063233:c988411-988109 [Pseudomonas fluorescens]
MIQFKKSKHFLEWLDSLRSKPARARVLARLDHAQWGNFGDCEALGNGVFEMRIHYGPGYRVYFTRRDEVVYLLLIGGDKS
TQKRDIQRAKQIAEDFEKKE

Nucleotide

• Length: 303 bp

>T177790 NZ_CP083690:c2610976-2610701 [Serratia sp. HRI]
ATGGCGTTAAAATGGACGAGTAAGGCGCTATCGGATTTGGCGCGTTTGTTTGAGTTTCTTGCCTTGGCTAACCGCACTGT
GGCAGCGAATTCGGTGAAGGCCTTGGTCGCCGCGCCTAAAGCGTTGCTTGATAATCCTCGCCTGGGTGAAAGACTGGATG
AGTTTTTACCGCAGGAAGTGAGACGTATTCTGGTCGGCCGTTATGAGATACGTTACCAGGTGCAGCCGGCAACGATTTAT
GTTCTGCGTATTTGGCATACCCGCGAAGAGCGATAG

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10391.78 Da
• Isoelectric Point: 4.4791

>AT177790 WP_024073150.1 NZ_CP063233:c988105-987818 [Pseudomonas fluorescens]
MNEFTDFDVAEHLKNPEDMAEYLEACFEEDTGDGLLIRSALNNIARAQGMTQVARDAGLGRESLYKALSSNGNPEFATIM
KVMKALGLKLHATAI

Nucleotide

• Length: 288 bp

>AT177790 NZ_CP083690:c2611236-2610976 [Serratia sp. HRI]
ATGAATACGAAAGTCATCACCGCTCATGTGCCGCTGCCTTTGGCTGAAAAGGTGGATGAAATGGCCGCCAAACTTGAACG
TTCACGGGGATGGATAGTGAAACAAGCCCTCGCCGCCTGGCTCGAACAAGAGGAAGAGCGCCGTCGGTTAACGCTGGCGG
CGTTGGTCGATGTCGAACAGCAAAACGTTATCGATCATGAGTCGGTAGAAGCCTGGGCTGCCAGCCTGGACAGTGACGAT
CCGCTGCCGGTACCGCGCTGA

Structures

Antitoxin

• AlphaFold DB: A0A855JY32