Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 5056274..5056866 Replicon chromosome
Accession NZ_CP063229
Organism Serratia marcescens strain LVF3

Toxin (Protein)


Gene name chpB Uniprot ID -
Locus tag IM817_RS24270 Protein ID WP_219228912.1
Coordinates 5056516..5056866 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID -
Locus tag IM817_RS24265 Protein ID WP_219228911.1
Coordinates 5056274..5056522 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IM817_RS24245 (IM817_24260) 5052092..5052430 + 339 WP_060660177.1 PTS lactose/cellobiose transporter subunit IIA -
IM817_RS24250 (IM817_24265) 5052427..5053734 + 1308 WP_219228909.1 6-phospho-beta-glucosidase -
IM817_RS24255 (IM817_24270) 5053807..5054787 + 981 WP_219228910.1 LacI family DNA-binding transcriptional regulator -
IM817_RS24260 (IM817_24275) 5054979..5056163 + 1185 WP_033636290.1 MFS transporter TsgA -
IM817_RS24265 (IM817_24280) 5056274..5056522 + 249 WP_219228911.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
IM817_RS24270 (IM817_24285) 5056516..5056866 + 351 WP_219228912.1 type II toxin-antitoxin system ChpB family toxin Toxin
IM817_RS24275 (IM817_24290) 5056863..5058146 - 1284 WP_219228913.1 cytosine deaminase -
IM817_RS24280 (IM817_24295) 5058435..5060984 + 2550 WP_219228914.1 nitrite reductase large subunit NirB -
IM817_RS24285 (IM817_24300) 5060981..5061307 + 327 WP_019456155.1 nitrite reductase small subunit NirD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-116)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12445.46 Da        Isoelectric Point: 11.5657

>T177788 WP_219228912.1 NZ_CP063229:5056516-5056866 [Serratia marcescens]
MVKRPVFQRGDLIRVSLNPVVGREQQGDFRPALVLSPREFNALGMVLVAPISQGANFARTAGFTVSLNGSGTATQGVILI
NQVRMMDLAGRSAQFVERVPGEVIADALARLQAIID

Download         Length: 351 bp

>T177788 NZ_CP083690:c2472989-2472714 [Serratia sp. HRI]
ATGCTCAACATCGAATGGACTCGAGTCGCACGTCAGGATCTGGGGGAGATTGTGGGATTTATCGCCAATGATAACCCTCT
GGCGGCCAGAAAAATGAAGGCTCTCATCATGGAGGCCGTCATTCCCGCCGCCAGACATCCTCGAATTTTCCGGCGCGGCA
GAGTGGACGGCACGCATGAAATCCCCCTGCATCCCCATTATCTCCTGGTTTACCAGGTGCTGGAAACTCACATCCGGGTG
TTGCGGGTTTTACATACGCGCCGACAATATCCTTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9099.56 Da        Isoelectric Point: 4.5026

>AT177788 WP_219228911.1 NZ_CP063229:5056274-5056522 [Serratia marcescens]
MKVFIKKWGNSAGMLVPSALMNELELQVGQEMDMQVIDGTLVIKPVKKRYSLQQLLDGCDGEAPAAADDNWEHMPPAGKE
VW

Download         Length: 249 bp

>AT177788 NZ_CP083690:c2473186-2472989 [Serratia sp. HRI]
ATGAGTATTTTACTGCTGCCTACGGTTGCCAAGATGGAAAATGAGGAGCGTACACAGGGCTATGAGCGCTGGTTTCTTGA
AAGAGTTCAGGAAGCCATGGATGAGCCACGGCCCGGTATTCCTCATGATGACGTGATGGCTGAAATGGATGCTGTTATCG
CTGCTGCAGAAGCCAGGATCAAAGCGAAGCAGGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References