Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 4606822..4607294 Replicon chromosome
Accession NZ_CP063229
Organism Serratia marcescens strain LVF3

Toxin (Protein)


Gene name relE Uniprot ID A0A5C7D428
Locus tag IM817_RS22100 Protein ID WP_049208401.1
Coordinates 4606822..4607097 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A5C7D116
Locus tag IM817_RS22105 Protein ID WP_049200097.1
Coordinates 4607103..4607294 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IM817_RS22075 (IM817_22080) 4602141..4603421 - 1281 WP_049272501.1 polysaccharide deacetylase family protein -
IM817_RS22080 (IM817_22085) 4603599..4604369 - 771 WP_219228677.1 ABC transporter permease -
IM817_RS22085 (IM817_22090) 4604366..4605289 - 924 WP_219228678.1 ABC transporter ATP-binding protein -
IM817_RS22090 (IM817_22095) 4605501..4606157 + 657 WP_219228679.1 carbonate dehydratase -
IM817_RS22095 (IM817_22100) 4606195..4606731 - 537 WP_048234659.1 hypoxanthine phosphoribosyltransferase -
IM817_RS22100 (IM817_22105) 4606822..4607097 - 276 WP_049208401.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IM817_RS22105 (IM817_22110) 4607103..4607294 - 192 WP_049200097.1 hypothetical protein Antitoxin
IM817_RS22110 (IM817_22115) 4607400..4609043 - 1644 WP_219228680.1 multicopper oxidase CueO -
IM817_RS22115 (IM817_22120) 4609262..4609609 + 348 WP_033634347.1 YacC family pilotin-like protein -
IM817_RS22120 (IM817_22125) 4609735..4610598 + 864 WP_219228681.1 polyamine aminopropyltransferase -
IM817_RS22125 (IM817_22130) 4610626..4611420 + 795 WP_141966679.1 adenosylmethionine decarboxylase -
IM817_RS22130 (IM817_22135) 4611453..4611815 - 363 WP_004937507.1 protein YacL -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-90)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10410.13 Da        Isoelectric Point: 6.8785

>T177786 WP_049208401.1 NZ_CP063229:c4607097-4606822 [Serratia marcescens]
MLTVKWTDEAKTGLYTLLAFIAERNPLAAEALLQRIEESVIPLAEHPYLFRPGRVNGTREMVVHPNYIVVYRVLAAHIEI
VSVLHARQEYP

Download         Length: 276 bp

>T177786 NZ_CP083690:1557919-1558122 [Serratia sp. HRI]
ATGACTAAAACCGACTATCTGATGCGTTTACGTAAATGCACCACGATTGATACTCTCGAACGTGTTATTGAGAAAAATAA
GTACGAGCTTTCCGATGATGAACTGGAGCTGTTTTACTCAGCGGCCGATCACCGTCTTGCGGAGCTCACCATGAACAAAC
TGTATGACAAAATCCCCACCTCCGTTTGGAAATATGTCAGGTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7188.98 Da        Isoelectric Point: 5.6492

>AT177786 WP_049200097.1 NZ_CP063229:c4607294-4607103 [Serratia marcescens]
MPTKLDPIVSEFETQEQADSYDRWFRSTVESSINSDSPRIPHDEVMAGARHIIEQAKAKRKSA

Download         Length: 192 bp

>AT177786 NZ_CP083690:1557500-1557868 [Serratia sp. HRI]
ATGGATGAGTATTCGCCTAAGCGACACGACATTGCTCAGCTCAAATTCTTGTGCGAAAATTTGTATGATGAAGGTATCGC
GACCTTGGGAGACAGCCACCACGGGTGGGTCAACGATCCGACATCCTCCGTCAACCTGCAGCTTAATGAGTTGATCGAAC
ATATCGCTTCGTTTGTGATGAGTTATAAAATTAAATACATGGACGAATCAGACCTGTCGGAGTTAGTCGAAGAATATCTC
GACGATACTTATACGCTGTTCAGCAGCTACGGTATCAATGATTCCGACCTGCGCCGCTGGCAAAAGACCAAGGCGAGATT
ATTCAGAATGTTCTCAGGAGAGGACATCTGTACGACAATGAAAACTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5C7D428

Antitoxin

Source ID Structure
AlphaFold DB A0A5C7D116

References