Detailed information of TA system TA177785

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 4471762..4472431
• Replicon: chromosome
• Accession: NZ_CP063229
• Organism: Serratia marcescens strain LVF3

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: IM817_RS21480
• Protein ID: WP_219228574.1
• Coordinates: 4471762..4472184 (-)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A8B4GS04
• Locus tag: IM817_RS21485
• Protein ID: WP_019455657.1
• Coordinates: 4472165..4472431 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IM817_RS21460 (IM817_21465)	4467651..4468169	+	519	WP_219228568.1	flavodoxin FldB	-
IM817_RS21465 (IM817_21470)	4468207..4469568	-	1362	WP_219228569.1	cell envelope integrity protein CreD	-
IM817_RS21470 (IM817_21475)	4469652..4471070	-	1419	WP_219228571.1	two-component system sensor histidine kinase CreC	-
IM817_RS21475 (IM817_21480)	4471067..4471762	-	696	WP_219228572.1	two-component system response regulator CreB	-
IM817_RS21480 (IM817_21485)	4471762..4472184	-	423	WP_219228574.1	protein YgfX	Toxin
IM817_RS21485 (IM817_21490)	4472165..4472431	-	267	WP_019455657.1	FAD assembly factor SdhE	Antitoxin
IM817_RS21490 (IM817_21495)	4472752..4473744	+	993	WP_219228575.1	tRNA-modifying protein YgfZ	-
IM817_RS21495 (IM817_21500)	4473783..4474280	-	498	WP_219228576.1	DUF2165 domain-containing protein	-
IM817_RS21500 (IM817_21505)	4474431..4475105	-	675	WP_033639467.1	hemolysin III family protein	-
IM817_RS21505 (IM817_21510)	4475288..4475896	+	609	WP_025304127.1	HD domain-containing protein	-
IM817_RS21510 (IM817_21515)	4475929..4476855	-	927	WP_038871218.1	ribokinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 16488.57 Da
• Isoelectric Point: 10.8114

>T177785 WP_219228574.1 NZ_CP063229:c4472184-4471762 [Serratia marcescens]
VAQWRCDIRISWRTQLFSLLTHGVLILLILISPWPEGFGPLWLVLLTLVVFQCIRSQKRIAAAQGELRLLAERRFSWHGR
EWRLAKKPWMPGYGMLLTLQPMEGKKRRRLWLASDCMSKEEWRHLRQLLLYPPAGDGEEA

Nucleotide

• Length: 423 bp

>T177785 NZ_CP083690:c995603-995295 [Serratia sp. HRI]
ATGCAATTTACCGTATATGACAATACGTATCCGGCATCAGCCTATCCCTACTTACTGGACGTTCAAAGCGATCTTATTGA
TGTCCTCTCGACCCGGTTAGTGATCCCTCTTTATGCTTTGGATAACGTCAGGGTTAAAATTTCTGCACGTTTATGCCCGG
AAATTGAGGTCAACGGCGAAAAGTTTCTTGTTATGACGCATGAGATGGCTGCCGTACGTATTTCGCAGATTGGGAAGGCC
GTTGGTAATGTCAATGAGCACAGGAATCAAATTAAAGCCGCTATCGATTTTCTGATTGATGGCTTTTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10417.91 Da
• Isoelectric Point: 4.7921

>AT177785 WP_019455657.1 NZ_CP063229:c4472431-4472165 [Serratia marcescens]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLNDADKALFIRLLECDDPDLFNWLMNHGAPQDSELQRMVTLIQTRN
KDRGPVAM

Nucleotide

• Length: 267 bp

>AT177785 NZ_CP083690:c995842-995606 [Serratia sp. HRI]
ATGGCAAATAACAATGTGACGAAAAAGACAGTCAACGTAACCATCGATCGCGATCTTTTCCAGCGCGCAAAATCCCTGGG
CGTCAATGTGTCATCCGTATTGACGGACGCATTGAGCGTCCGCGTCAGGGATATTGAGATTCAACAGTGGCGCGAGCAAA
ATCGCGCGGCGTTAGAAGAACTTAATCGTATCACTGAAGAAAATGGTTTGTTGTCTGATGAATATCGGACATTTTAA

Structures

Antitoxin

• AlphaFold DB: A0A8B4GS04