Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ypjF-yeeU/CbtA-CbeA
Location 1263753..1264519 Replicon chromosome
Accession NZ_CP063229
Organism Serratia marcescens strain LVF3

Toxin (Protein)


Gene name ypjF Uniprot ID -
Locus tag IM817_RS06000 Protein ID WP_219229662.1
Coordinates 1264151..1264519 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag IM817_RS05995 Protein ID WP_219229661.1
Coordinates 1263753..1264091 (+) Length 113 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IM817_RS05970 (IM817_05985) 1259417..1259581 + 165 WP_219229657.1 hypothetical protein -
IM817_RS05975 (IM817_05990) 1260109..1261269 + 1161 WP_219229658.1 putative lipopolysaccharide heptosyltransferase III -
IM817_RS05980 (IM817_05995) 1261322..1262566 + 1245 WP_219229659.1 O-antigen ligase family protein -
IM817_RS05985 (IM817_06000) 1262761..1263219 + 459 WP_219229660.1 antirestriction protein -
IM817_RS05990 (IM817_06005) 1263245..1263724 + 480 WP_219230637.1 DNA repair protein RadC -
IM817_RS05995 (IM817_06010) 1263753..1264091 + 339 WP_219229661.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
IM817_RS06000 (IM817_06015) 1264151..1264519 + 369 WP_219229662.1 TA system toxin CbtA family protein Toxin
IM817_RS06005 (IM817_06020) 1264516..1264845 + 330 WP_077038884.1 DUF5983 family protein -
IM817_RS06010 (IM817_06025) 1264944..1265117 + 174 WP_219229663.1 hypothetical protein -
IM817_RS06015 (IM817_06030) 1266264..1266839 + 576 WP_219229664.1 acyltransferase -
IM817_RS06020 (IM817_06035) 1267064..1267207 + 144 WP_015376917.1 hypothetical protein -
IM817_RS06025 (IM817_06040) 1267333..1268865 + 1533 WP_219229665.1 glycosyltransferase family 39 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1227893..1267207 39314


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-111)

Antitoxin

Antitoxin CbeA

(9-107)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13356.29 Da        Isoelectric Point: 8.5227

>T177771 WP_219229662.1 NZ_CP063229:1264151-1264519 [Serratia marcescens]
MRTVHAPTSRAAQTCPSPITVWQSLLTYLLAQHYGLTLNDTAFSDDAVIQSHIDDGISLADTLNAMVEKFDLVRIDRRGF
SGLAQSPLVTAIDILRARRACGLMTRAGYREVTRAIQGGKQP

Download         Length: 369 bp

>T177771 NZ_CP083658:c1137518-1137330 [Acinetobacter variabilis]
ATGAACAGCAAAGATATTATTAAGCGTCTAGAGCAGGAAGGCTGGTATAAGGTTGGCGGTAAGGGCGACCATGAAAAGTA
CAAGCATCCTGAAAAGTCCGGGCATGTTGTGGTGCCACATCCACGTAAAGATATGCCGATAGGAACTCTACGCAATATAT
ATAAACAGGCTGGTTGGGAATGGAGGTAA

Antitoxin


Download         Length: 113 a.a.        Molecular weight: 12788.57 Da        Isoelectric Point: 6.6295

>AT177771 WP_219229661.1 NZ_CP063229:1263753-1264091 [Serratia marcescens]
MTSTKNVPSWGLKRNVTPQFGARLVQEGERLHFLADRADISGIFSDVQRHDLEKAFPQFINHLELMLLSGELNPRYQHCV
TLYCHGLTCEADSLGSYGYVYLSIYPTPEMPR

Download         Length: 339 bp

>AT177771 NZ_CP083658:c1137327-1136941 [Acinetobacter variabilis]
ATGTTATATCCAGTATATGTTCATAAAGATGAAGATACTGCATACGGTTTAACTTTCCCTGACTTTGAAGGGTGTTTCAG
TGCTGCTGATGAAATGCAAGACATCCAGCGCATGGCGCAGGAAGCGGTTGAAGTTCACTTTGATGGTGAAGATATTCCGT
TACCTACACCGTCAAGCCCGGAACAATGGTTAAGTGATGAGAGATTTGAAGGTGGTTTTTGGTTGTTAGTTGATATTGAT
ACAGCAAAGGTAAATACCAAGTCTGTTCGTATTAATATCAGCATGCCAGAAGCTTTAGTGAAACGTATTGATGCTATGGC
TAAAAAACAACATTTAAGCCGTTCGGCATTTTTAGCCAAAAGCGCGGAAATGGCATTGCATCAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References