Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 91624..92276 Replicon plasmid pHKU57_1
Accession NZ_CP063216
Organism Klebsiella pneumoniae strain HKU57

Toxin (Protein)


Gene name vagD Uniprot ID A0A8A2Q2K1
Locus tag IM695_RS25645 Protein ID WP_017901321.1
Coordinates 91624..92049 (-) Length 142 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A853H7M9
Locus tag IM695_RS25650 Protein ID WP_001261275.1
Coordinates 92046..92276 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IM695_RS25620 87351..88319 + 969 WP_077268726.1 IS5-like element IS903B family transposase -
IM695_RS25625 88705..89265 - 561 Protein_97 transposase -
IM695_RS25630 89300..89875 - 576 Protein_98 IS5 family transposase -
IM695_RS25635 89889..91097 - 1209 WP_001339197.1 IS4-like element ISVsa5 family transposase -
IM695_RS25640 91202..91606 - 405 Protein_100 transposase -
IM695_RS25645 91624..92049 - 426 WP_017901321.1 type II toxin-antitoxin system VapC family toxin Toxin
IM695_RS25650 92046..92276 - 231 WP_001261275.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
IM695_RS25655 92529..95105 - 2577 WP_017901322.1 EstP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid mph(A) / sul1 / qacE / dfrA25 / aph(6)-Id / aph(3'')-Ib / aph(3')-Ia / mph(E) / msr(E) / armA / blaDHA-1 / qnrB4 - 1..273789 273789


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15412.91 Da        Isoelectric Point: 7.1364

>T177750 WP_017901321.1 NZ_CP063216:c92049-91624 [Klebsiella pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQVVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNTREFERVPGLVLEDWVGFVE

Download         Length: 426 bp

>T177750 NZ_CP083648:2429599-2429892 [Corynebacterium coyleae]
GTGAAGGAAGTAACATTTTCAGCGTTCGATGCAAGCAAATATCTCGATAGCCAAGAAGCAGTGAACGATTACCTGGCTAT
CGCACTCGAAGACGGCGATACGAAAACCGTTCAGGTGGTTTTGCGTGACATTGCAAGGGCACACGGCATGAGCCAGCTCG
CTAAAGAGACTCAACTCAACCGTGAATCCCTCTACAAGTCACTATCAAAAGACGGTAACCCGTCCTTTGCGGCTATCACG
AAAATCATGAAAGCCCTGGGACTCAAAATAACTCTCGCTACACAAAATGCCTAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8707.72 Da        Isoelectric Point: 4.3410

>AT177750 WP_001261275.1 NZ_CP063216:c92276-92046 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFDP

Download         Length: 231 bp

>AT177750 NZ_CP083648:2429294-2429602 [Corynebacterium coyleae]
GTGGAGATCATTTCCAGCAGCTTGTTTGACGCCTGGTTAGGTGAGCTAAAAGACAAACATGCTCAGCGACGCATTTTGTA
TGCAATAGCCCGATGCGAAGCACACGGAAGAATGATTGGAGACATCAAACCCGTTGGCGAGAAGGTTAGCGAGATGAGAT
TTCATTTCGGGCCCGGCTATCGGGTGTACTACACCCGACTAGGCGCAATAACGGTTTTCCTGCTGGCCGGAGGAGATAAA
TCCAGCCAGGATAAAGATATTCGAACCGCTCAAAAGCTCGCACAACAGGTAAGGGAGGAACAGTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8A2Q2K1

Antitoxin

Source ID Structure
AlphaFold DB A0A853H7M9

References