Detailed information of TA system TA177746

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4843157..4844838
• Replicon: chromosome
• Accession: NZ_CP063215
• Organism: Klebsiella pneumoniae strain HKU57

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: IM695_RS23335
• Protein ID: WP_004178299.1
• Coordinates: 4843157..4844074 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A6TH05
• Locus tag: IM695_RS23340
• Protein ID: WP_004177809.1
• Coordinates: 4844080..4844838 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IM695_RS23315	4838463..4839983	+	1521	WP_002885173.1	sugar ABC transporter ATP-binding protein	-
IM695_RS23320	4839980..4840978	+	999	WP_002885172.1	ribose ABC transporter permease	-
IM695_RS23325	4841009..4841950	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
IM695_RS23330	4842025..4843032	+	1008	WP_004178300.1	carbohydrate kinase family protein	-
IM695_RS23335	4843157..4844074	-	918	WP_004178299.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
IM695_RS23340	4844080..4844838	-	759	WP_004177809.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
IM695_RS23345	4844924..4845652	-	729	WP_004178298.1	response regulator transcription factor	-
IM695_RS23350	4845925..4848072	+	2148	WP_012737173.1	formate dehydrogenase H subunit alpha, selenocysteine-containing	-
IM695_RS23355	4848069..4848212	-	144	WP_022631365.1	hypothetical protein	-
IM695_RS23360	4848650..4849336	+	687	WP_004151733.1	sel1 repeat family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34649.06 Da
• Isoelectric Point: 5.4707

>T177746 WP_004178299.1 NZ_CP063215:c4844074-4843157 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPSQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

>T177746 NZ_CP083648:c1483952-1483692 [Corynebacterium coyleae]
ATGATTCTATCTTGGGACGAAGATGCCTGGGCCGAGTATGTCGAATGGCAAACCACGGACAAGCGTGTGCTCAAACGCAT
CAACATGCTCATCCGCGATATTCAACGCAACGGCAATCAAGGCATCGGCAAGCCTGAACCGCTCAAACATGAGCTCAGTG
GCTATTGGTCCCGGAGGATTACCAGCGAGCACCGACTCGTGTACAAAATGACCGAAACCGAGATCCGAATTGCGGCTTGT
CGCTACCACTACGGGGAATAG

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28548.92 Da
• Isoelectric Point: 10.0870

>AT177746 WP_004177809.1 NZ_CP063215:c4844838-4844080 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

>AT177746 NZ_CP083648:c1484209-1483949 [Corynebacterium coyleae]
ATGAAAGTCATGTCTTACTCGGAATCTCGTGCAAACTACGCGGAGGTTCTGAACACAGTTGTTGACGATTGCGAGGAGGT
CGTCATCACCCGTTCCGGCCACGATCCGGTTGTCATTGTCTCGCTGGCGGAATACGAATCGATGAAGGAGACCTCTTATT
TGCTTCAATCCCCAGCGAATGCCCGCGTACTCAAGGAGCGAATCGAACGCTTGGAGAAAGGAACGTCGGTTCAAAATGAG
CTCATCGAGGACGATAGATGA

Structures

Antitoxin

• AlphaFold DB: A6TH05