Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4687461..4687977 Replicon chromosome
Accession NZ_CP063215
Organism Klebsiella pneumoniae strain HKU57

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag IM695_RS22545 Protein ID WP_004178374.1
Coordinates 4687461..4687745 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag IM695_RS22550 Protein ID WP_002886901.1
Coordinates 4687735..4687977 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IM695_RS22520 4682945..4683253 - 309 WP_022631369.1 PTS sugar transporter subunit IIB -
IM695_RS22525 4683338..4683511 + 174 WP_032408826.1 hypothetical protein -
IM695_RS22530 4683514..4684257 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
IM695_RS22535 4684614..4686752 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
IM695_RS22540 4686993..4687457 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
IM695_RS22545 4687461..4687745 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IM695_RS22550 4687735..4687977 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
IM695_RS22555 4688055..4689965 - 1911 WP_004178373.1 BglG family transcription antiterminator -
IM695_RS22560 4689988..4691142 - 1155 WP_004178372.1 lactonase family protein -
IM695_RS22565 4691209..4691949 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T177745 WP_004178374.1 NZ_CP063215:c4687745-4687461 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T177745 NZ_CP083648:1230285-1230539 [Corynebacterium coyleae]
ATGCGGCTTGTGTGGACCACCAACGCGTGGGAGGACTACCTGTACTGGCAGGGCAACGACAAGAAAACGCTGAGGCGAGT
CAACCAGCTTCTGCGCGACACCTTAAGGGATCCGTTTGAAGGCATAGGGAAACCCGAACCGCTGAAGTACGGAGCTGAAG
GGGCGTGGTCGAGGAGGATCACGCAAGAACACCGCTTGGTCTATACGGTCGCTGGGACAGATTTGGTGATTCTCCAAGCC
CGGTACCACTACTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT177745 WP_002886901.1 NZ_CP063215:c4687977-4687735 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT177745 NZ_CP083648:1230034-1230285 [Corynebacterium coyleae]
ATGTCTATCAGTGCATCTGAAGCGCGGCGCACGCTATATCCGCTCATCGAGCGTGTGAACAATGATCGCGATCCCGTTGA
AATCGTGTCGCGTCACGGTAATGCAGTATTGATGGCTGCAGATGACTACGCGGCATGGGTTGAGACTGCCTACCTGTTTA
AGTCGCCAGAGAATGCTCGACGCCTGACTCAGGCCTACGAGGAAGCACTCAACGGGGCGGTGGCCGAACACGACATCGAC
CTGGACGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References