Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 843562..844219 Replicon chromosome
Accession NZ_CP063215
Organism Klebsiella pneumoniae strain HKU57

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag IM695_RS04165 Protein ID WP_002916310.1
Coordinates 843809..844219 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag IM695_RS04160 Protein ID WP_002916312.1
Coordinates 843562..843828 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IM695_RS04135 838718..840151 - 1434 WP_004185559.1 6-phospho-beta-glucosidase BglA -
IM695_RS04140 840270..840998 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
IM695_RS04145 841048..841359 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
IM695_RS04150 841523..842182 + 660 WP_002916317.1 hemolysin III family protein -
IM695_RS04155 842333..843316 - 984 WP_020324927.1 tRNA-modifying protein YgfZ -
IM695_RS04160 843562..843828 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
IM695_RS04165 843809..844219 + 411 WP_002916310.1 protein YgfX Toxin
IM695_RS04170 844226..844747 - 522 WP_004144730.1 flavodoxin FldB -
IM695_RS04175 844848..845744 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
IM695_RS04180 845767..846480 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
IM695_RS04185 846486..848219 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T177732 WP_002916310.1 NZ_CP063215:843809-844219 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T177732 NZ_CP083641:1538899-1539399 [Enterobacter bugandensis]
ATGTTTTCAGAGGGAACCGACTATGATTTCGGGGATTTTGATTGTGGTGAACCCTCGCTAAATGCCTTCCTGAGAGAACA
CCTGGTACGCCAGCACAATGGACGTATTCTACGAGCCTACCTGCTTAAAGAGCGCGACCATCCGCGCGTGCTGGGCTATT
ACACGCTATCGGGAAGTTGCTTTGAGAGAGCGATGCTTCCTTCTAAGACCCAGCAGCGTCGGATCCCTTATCTCAACGTA
CCCAGCGTGACGCTGGGACGTCTGGCTATTCATAAAGAACTACAGGGAAACGAGTGGGGAACAACGCTTGTTGCACACGC
TATGCGGGTGGTTTACCTGGCGTCGCAGGCTGTGGGAGTACATGGAATATTTGTTGATGCCCTTAGCGAGCAGGCTAAAC
GATTTTATCTGAAGCTGGGGTTCATCCCGCTGGCAGGCGAAAACAGCCATTCTTTGTTCTTCCCGACAAAAGCTATCGAA
CGACTGTTTGAGCAGGCGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT177732 WP_002916312.1 NZ_CP063215:843562-843828 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT177732 NZ_CP083641:1538602-1538871 [Enterobacter bugandensis]
ATGCCAGCACTTAAAAAACAGCGTATCGATCTTCGCTTAACGGACGAAGACAAAACAATGATTGAAGAAGCGGCGGCGAT
GACGAATCAAACGATCACCCAGTTTATGGTGAACAGTGCGTCAGAGCGTGCTGCAGAGGTCATCGAGCAGCACCGTCGTC
TCGTGTTAAACGAAGCCTCCTGGAATGCGGTGATGGATGCTATCGACAATCCGCCAGAGCCAAATGAACGCCTCAAGCGA
GCGGCAAAACGTCTTCGAAACATGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References