Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 696925..697604 Replicon chromosome
Accession NZ_CP063215
Organism Klebsiella pneumoniae strain HKU57

Toxin (Protein)


Gene name ykfI Uniprot ID A0A0C7K7A4
Locus tag IM695_RS03420 Protein ID WP_020324801.1
Coordinates 697263..697604 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A0C7KEL2
Locus tag IM695_RS03415 Protein ID WP_020324792.1
Coordinates 696925..697242 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IM695_RS03390 692139..695291 + 3153 WP_022631414.1 AIDA repeat-containing protein -
IM695_RS03395 695384..695623 + 240 WP_020324820.1 DUF905 domain-containing protein -
IM695_RS03400 695726..696184 + 459 WP_020324813.1 antirestriction protein -
IM695_RS03405 696200..696676 + 477 WP_020324797.1 RadC family protein -
IM695_RS03410 696685..696912 + 228 WP_020324796.1 DUF987 domain-containing protein -
IM695_RS03415 696925..697242 + 318 WP_020324792.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
IM695_RS03420 697263..697604 + 342 WP_020324801.1 TA system toxin CbtA family protein Toxin
IM695_RS03425 697720..698553 + 834 WP_020324805.1 DUF4942 domain-containing protein -
IM695_RS03435 698856..699362 + 507 WP_002917636.1 G/U mismatch-specific DNA glycosylase -
IM695_RS03440 699462..701303 - 1842 WP_004174339.1 RNA polymerase sigma factor RpoD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-111)

Antitoxin

Antitoxin CbeA

(5-103)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12818.91 Da        Isoelectric Point: 9.1484

>T177731 WP_020324801.1 NZ_CP063215:697263-697604 [Klebsiella pneumoniae]
MKTLPAIISRAAKPCLSPVAVWQMLLTRLLEKHYGLTLNDTPFCDETVIQEHIDAGITLADAVNFLVEKYGLVRIDRNGF
VWQEQSPYLRAVDILRARQATGLLRQSRNNAIR

Download         Length: 342 bp

>T177731 NZ_CP083641:c1406297-1405824 [Enterobacter bugandensis]
ATGATTTTTTATCGGCTGGTGACGGGACGCTATGCCAGCGAAGCGTGGAGTGGAAGCGGCGCAAATCAGTACGGTGGTCG
CTGGAATCATAAAGGGCATCCCGCCGTATATGTGTCCACGTCCATCTCGCTGGCCTCACTGGAGATTTTGGTGCACATCA
GAAAAGATACCGTGTTGAATCAGTACCAGCTTTTCAGCATTGATATCCCGGATGACCAGATTGATTACCTGGATAAAGCC
TGGCTCCCCGAGGACTGGCAGGAAAATCCGGCACCGGTATCGACGATGGATCTGGGAACCGGGTGGTTGCAGGCTAGCAG
TGCCCTCGCGCTTATCCTACCTTCCTGCATCATACCCTATGAAAACAACGCCATCCTTAACCCCTTACATCCGGCATTCC
ATACGGCGCTCAGTTCTGTTCAGCAGATGCCCTTTATTTTTGATACCCGTCTCGCAGAAAAAACCGCACCCTGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11915.51 Da        Isoelectric Point: 6.6246

>AT177731 WP_020324792.1 NZ_CP063215:696925-697242 [Klebsiella pneumoniae]
MSNITWGLQRDTTPRLGARLVQEGNQLHYLADRASMTGKFSDAECRKLDETFPHFISQMESMLITGEMNPRHAHCVTLYH
NGFTCEADTLGSCGYVYIAVYPIQR

Download         Length: 318 bp

>AT177731 NZ_CP083641:c1406737-1406294 [Enterobacter bugandensis]
ATGAGAACCTGGATCCCCGCCAAGAAACCTGCTGATAACGCACTTTGGCGCTATGCCGGTTTACCCGCGAACAGAGGTAT
GCGGCTGATAGAATTTCTCAACCAGGGATTGCCCGTCAGCGTGCTCGACAATATTCATGAATGGACGGCCATGTCGAAAG
CGGACATTTTGCGCGTTACCGGGATTAACGAACGTAACGTGGCCCGCCGCAAAAGCGCGGGACGGACGCTGACGCCGGAT
GAGAGCGAACGCGTAGCCCGTTTTGTTCGGGTGCTGGATGCGGCCGTCGACTATTTTGGCAGTAAAGAAGAAGCATGGAA
CTGGCTTCAGTCGCCGGTGCGCGGGCTTGGCAATGTTGCGCCTGTTGACCTGATCGCTACGGAAACCGGTGCACTGGAAG
TCACCGATTTGATTGGTCGTCTGGAACACGGAGTGTTTGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C7K7A4

Antitoxin

Source ID Structure
AlphaFold DB A0A0C7KEL2

References